Results 61 to 70 of about 13,350,536 (306)

CAF and CAMM analyses on the first 10 years of national Kanta services in Finland

Finnish Journal of eHealth and eWelfare, 2020
We report the large-scale deployment, implementation and adoption of the nationwide centralized integrated and shared Kanta health information services by using the Clinical Adoption Framework (CAF).
Vesa Jormanainen, Jarmo Reponen
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Cassandra Method: Dystopian Visions as a Basis for Responsible Design

Engineering Proceedings
Innovative technologies often have unforeseen negative consequences on an individual, societal, or environmental level. To minimize these, the Cassandra method aims to foresee such negative effects by systematically investigating dystopian visions ...
Sarah Diefenbach, Daniel Ullrich
doaj   +1 more source

Demokratie und Technikfolgenabschätzung

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2020
Technikfolgenabschätzung (TA) ist vor über 50 Jahren zur Unterstützung demokratischer Meinungsbildung und Entscheidungsfindung entstanden. Sie hat sich seitdem in demokratischen Gesellschaften westlichen Typs weiterentwickelt und diversifiziert.
Armin Grunwald, Thomas Saretzki
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Technology or practices of care first?: Technology assessment in the tension between ‘technology push’ and managing socio-technological futures

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis
The article underscores the crucial role of technology assessment (TA) in balancing technological development with care principles. While TA integrates care-based approaches, it is evident that these efforts alone are not sufficient to promote truly ...
Bettina-Johanna Krings, Nora Weinberger
doaj   +1 more source

Identification and Analysis of 4th Generation Engine Manufacturing Project’s Risks Based on PMBOK Practice Standard [PDF]

بهبود مدیریت, 2014
Being at the cutting edge of technology, only a handful of countries have the exclusive capability to design and manufacture the turbine engine. Developing and producing high-performance engines could be the toughest - but most rewarding-advance for any ...
Fakhredin Naderi, Manochehr Manteghi, Ali Safaei Moghaddam   +2 more
doaj  

Technology Assessment in a Globalized World

Management Systems in Production Engineering, 2019
The interaction between science and policy is affected by increasingly dissolving boundaries whereby a number of issues arise, such as, what should political advice for national parliaments consist of in the face of global socio-technical developments ...
Scherz Constanze, Hahn Julia, Ladikas Miltos   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Technology Assessment Framework of Social Network Games [PDF]

بهبود مدیریت, 2017
Industry of video games, especially social network ones, has become one of the main parts of creative industries. Development of knowledge based businesses, different technology platforms, rapid technology growth rate and social impacts of these games ...
Mohammad Naqizade, Mehdi Eliasi, Pejman Hakimi   +2 more
doaj