Results 61 to 70 of about 1,219,886 (310)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Responsible AI in Farming: A Multi-Criteria Framework for Sustainable Technology Design

Applied Sciences
The continuous fusion of artificial intelligence (AI) and autonomous farming machinery (e.g., drones and field robots) provides a significant shift in the daily work experience of farmers.
Kevin Mallinger, Ricardo Baeza-Yates
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Die digitale Selbstvermessung in Lifestyle und Medizin

Technikfolgenabschätzung – Theorie und Praxis, 2011
Die digitale Selbstvermessung, auch Quantified Self (QS) genannt, bezeichnet das Messen und Aufzeichnen von Körperparametern und -zuständen mittels Anwenderprogrammen (Apps) und Wearables.
Mandy Scheermesser, Ursula Meidert, Michaela Evers-Wölk, Yvonne Prieur, Stefan Hegyi, Heidrun Becker   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A consistent conceptual framework for applying climate metrics in technology life cycle assessment

Environmental Research Letters, 2017
Comparing the potential climate impacts of different technologies is challenging for several reasons, including the fact that any given technology may be associated with emissions of multiple greenhouse gases when evaluated on a life cycle basis.
Dharik Mallapragada, Bryan K Mignone
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

HTA und aktuelle Herausforderungen: Harmonisierung, Real World Data und Surrogatparameter

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2018
Health Technology Assessment is one of the standard instruments in support of the decision-making to define the public health services both internationally and in the German health care system.
Rüther, Alric, Herrmann, Kirsten H., Hebborn, Ansgar, Perleth, Matthias, Schwarzer, Ruth, Schürmann, Christoph, Sieben, Wiebke, Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm, Schramm, Wendelin   +11 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source