Results 91 to 100 of about 7,620,387 (307)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Microelectronic device data handbook [PDF]
, 1969 Handbook provides general guidance to the technology of integrated circuits for readers with little or no experience.
core +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Functional planning and occupational safety of milk production in cold loose housing barns [PDF]
, 2004 The study charted the most serious occupational hazards of cold loose housing barns. Furthermore, the study gave a good general picture of cold loose housing barns (CLHB) in dairy production.
Karttunen, Janne
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Is a general extended technology acceptance model for e-learning generalizable?
Knowledge Management & E-Learning: An International Journal, 2018 e-Learning acceptance has received considerable attention in the educational technology literature. In recent years, many frameworks have been proposed, modified, and applied to better understand the factors underlying students’ acceptance of e-learning.
Tenzin Doleck +2 more
doaj
Social approaches to technological systems
Trilogía Ciencia Tecnología Sociedad, 2014 this article presents a characterization of technological systems from social approaches. This is a set of elements that seek to define both the functioning and the role of people in technological systems.
Carlos Osorio Marulanda
doaj +1 more source
Research and technology program perspectives for general aviation and commuter aircraft [PDF]
The uses, benefits, and technology needs of the U.S. general aviation industry were studied in light of growing competition from foreign general aviation manufacturers, especially in the commuter and business jet aircraft ...
Bauchspies, J. S., Simpson, W. E.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source