Results 141 to 150 of about 8,042,294 (313)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Embrapa Technological Information: a bridge between research and society [PDF]

, 2009
This paper presents the efforts undertaken by the Brazilian Agricultural Research Corporation regarding Science and Technology information management, through one of its Decentralized Units, Embrapa Technological Information (Scientific and Technological
Bertin, Patrícia Rocha Bello, Leite, Fernando César Lima, Pereira , Fernando do Amaral   +2 more
core  

Technological Understanding: On the cognitive skill involved in the design and use of technological artefacts [PDF]

arXiv
Although several accounts of scientific understanding exist, the concept of understanding in relation to technology remains underexplored. This paper addresses this gap by proposing a philosophical account of technological understanding - the type of understanding that is required for and reflected by successfully designing and using technological ...
arxiv  

Data-Driven Investment Decision-Making: Applying Moore's Law and S-Curves to Business Strategies [PDF]

arXiv, 2018
This paper introduces a method for linking technological improvement rates (i.e. Moore's Law) and technology adoption curves (i.e. S-Curves). There has been considerable research surrounding Moore's Law and the generalized versions applied to the time dependence of performance for other technologies.
arxiv  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Production Under Uncertainty: A Simulation Study [PDF]

In this article we model production technology in a state-contingent framework. Our model analyzes production under uncertainty without being explicit about the nature of producer risk preferences. In our model producers’ risk preferences are captured by
Chris O'Donnell, John Quiggin, Sriram Shankar   +2 more
core   +3 more sources

Research and technology program perspectives for general aviation and commuter aircraft [PDF]

The uses, benefits, and technology needs of the U.S. general aviation industry were studied in light of growing competition from foreign general aviation manufacturers, especially in the commuter and business jet aircraft ...
Bauchspies, J. S., Simpson, W. E.
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

TRADE-INDUCED TECHNOLOGY SPILLOVER AND ADOPTION: A QUANTITATIVE GENERAL EQUILIBRIUM APPLICATION [PDF]

This paper investigates the impact of a 4% Hicks-neutral technical progress in heavy manufacturing in the United States and its trans-border spillover via intermediates.
Gouranga Gopal Das
core