Results 51 to 60 of about 1,961 (137)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Synergistic Phytochemicals From Mitracarpus frigidus (Willd. ex Roem. & Schult.) K. Schum. and Lantana camara Linn. in Chitosan Biofilms: Antioxidant and Anti‐Inflammatory Activities With Wound‐Healing Potential

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Biodegradable chitosan films loaded with a 1:1 combination of Mitracarpus frigidus and Lantana camara extracts demonstrated potent antioxidant, anti‐inflammatory, and wound‐healing properties, while exhibiting low cytotoxicity and favorable physicochemical characteristics.
Natasha Silva Mayrink, Julia Bertolini Fajardo, Mariane Rocha Cordeiro Comitre, Lucas de Araújo Carvalho, Mariana Iasbeck Dalcol, Priscila de Lima Paula, Lara Melo Campos, Maria Clara Machado Resende Guedes, Luiz Fernando Cappa de Oliveira, Elaine Soares Coimbra, Gilson Costa Macedo, Ângelo Márcio Leite Denadai, Ari Sérgio de Oliveira Lemos, Rodrigo Luiz Fabri   +13 more
wiley   +1 more source

Excipiente para a produção de comprimidos por compressão direta [PDF]

Infarma: Pharmaceutical Sciences, 2013
O interesse da indústria farmacêutica na produção de comprimidos através da compressão direta tem aumentado nos últimos anos, principalmente por ser um método de produção de fácil controle e com menor tempo de processo, levando a uma maior ...
Tiago Rafael SAUSEN, Paulo MAYORGA
doaj  

Micro‐QuEChERS Extraction for Broad‐Spectrum LC‐QQQ‐MS Quantification of Nitazene Analogs in Plasma: A Validated Method With Casework Application

Drug Testing and Analysis, Volume 18, Issue 10, Page 1296-1310, October 2026.
Micro‐QuEChERS sample preparation coupled to LC‐QQQ‐MS enabled sensitive quantification of nitazene analogs in 100 μL of plasma. The validated method provided low detection limits and was successfully applied to an authentic intoxication case involving N‐pyrrolidino protonitazene, supporting clinical and forensic toxicology workflows.
Karla A. O. Souza, Náthaly C. B. F. Santos, Rafael Lanaro, Sara E. Walton, Alex J. Krotulski, Barry K. Logan, Mauricio Yonamine, Jose Luiz Costa   +7 more
wiley   +1 more source

Bioremediation of Olein Industry Waste by Cytobacillus sp. OWB‐43 Strain

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Cytobacillus sp. OWB‐43 can bioremediate residue provided from edible oil refining. The bacterium reduces toxicity, chemical oxygen demand, and soluble solids, enabling safe disposal and supporting plant growth—offering a sustainable solution for waste from sunflower, soybean, corn, and peanut oil industries.
Julián Escalante, Nicolás Lencina, Ainelén Piazza, Paula Burdisso, Mario O. Salazar, Ricardo L. E. Furlan, Natalia Gottig, Jorgelina Ottado, Betiana Garavaglia   +8 more
wiley   +1 more source

Optimization of Salt Composition and Influence of β‐Lactoglobulin Nanostructures on the Physicochemical and Textural Properties of Minas Frescal Cheese

Journal of Texture Studies, Volume 57, Issue 5, October 2026.
A central composite rotatable design was used to evaluate the effects of sodium chloride (NaCl), potassium chloride (KCl), and β‐lactoglobulin (β‐lg) nanostructure concentrations on the physicochemical and textural properties of Minas Frescal cheese.
Brunna D'Onofre Couto, Igor José Boggione Santos   +1 more
wiley   +1 more source

<b> Assistência farmacêutica como um modelo tecnológico em atenção primária à saúde </b>

Revista de Ciências Farmacêuticas Básica e Aplicada, 2009
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> A Assistência Farmacêutica foi analisada neste artigo, como tecnologia em saúde.
A. L.A. ARAúJO, J. M. UETA, O. FREITAS
doaj  

Simultaneous Infection With Genetically Distinct Trypanosoma cruzi Isolates Is Associated With Distinct Myocardial Innate Immune Transcriptional Profiles During Acute Infection in Mice

Parasite Immunology, Volume 48, Issue 10, October 2026.
ABSTRACT Innate immune receptors are central to host resistance against Trypanosoma cruzi infection, yet how parasite genetic diversity is associated with these responses remains poorly understood. Here, we characterized acute infection outcomes and myocardial innate immune transcriptional profiles in mice subjected to single and mixed infections with ...
George Harisson Felinto Sampaio, Andressa Noronha Barbosa‐Silva, Carlos Ramon do Nascimento Brito, Lucas Abrantes Batista, Christiane Carlos Araújo de Negreiros, Ramayana Morais de Medeiros Brito, Rand Randall Martins, Manuela Sales Lima Nascimento, Antonia Claudia Jácome da Câmara, Paulo Marcos da Matta Guedes, Lúcia Maria da Cunha Galvão   +10 more
wiley   +1 more source

Triplet Acetone Generation by Pseudoperoxidase Activity of Myoglobin: Structural Damage and Quenching

Luminescence, Volume 41, Issue 9, September 2026.
Ferrimyoglobin pseudoperoxidase activity was demonstrated during isobutyraldehyde oxidation, yielding electronically excited triplet acetone and inducing structural damage. Sorbates and 9,10‐dibromoanthracene‐2‐sulfonate exhibited protective effects.
Thiago M. V. Gomes, Cassius V. Stevani, Kostas Pantopoulos, Luiz D. Ramos, Etelvino J. H. Bechara   +4 more
wiley   +1 more source

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source