Results 41 to 50 of about 1,904 (138)

Chemical Characterization and In Vivo Safety Assessment of Aqueous Extract From Anacardium occidentale L. (Anacardiaceae) Leaves

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Anacardium occidentale leaf aqueous extract showed rich polyphenolic composition, including flavonoids, tannins, and phenolic acids. Acute toxicity in mice revealed no mortality or adverse effects, with LD50 >2000 mg/kg and GHS Class 5. Genotoxicity assays were negative, supporting safety and potential phytopharmaceutical development, pending chronic ...
Elinado Francisco de Lima Bento, Caio Everton Nunes da Silva, Talita Giselly dos Santos Souza, Camylla Janiele Lucas Tenório, Natanael Teles Ramos de Lima, Cristiano Aparecido Chagas, José Maria Barbosa Filho, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Samuel Paulo Cibulski, Alisson Macário de Oliveira, Thiago Henrique Napoleão   +11 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Excipiente para a produção de comprimidos por compressão direta [PDF]

Infarma: Pharmaceutical Sciences, 2013
O interesse da indústria farmacêutica na produção de comprimidos através da compressão direta tem aumentado nos últimos anos, principalmente por ser um método de produção de fácil controle e com menor tempo de processo, levando a uma maior ...
Tiago Rafael SAUSEN, Paulo MAYORGA
doaj  

Role of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on immediate implant placement in type 2 diabetic rats

Photochemistry and Photobiology, Volume 102, Issue 4, Page 934-948, July/August 2026.
This study evaluated the combined effects of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on bone repair around immediately placed implants in type 2 diabetic rats. Resveratrol improved glycemic control and body weight, while aPDT increased implant stability and bone mineralization.
Letícia Pitol‐Palin, Carolina Sayuri Wajima, Fábio Roberto de Souza Batista, Naara Gabriela Monteiro, Isadora Castaldi Sousa, Valdir Gouveia Garcia, Dóris Hissako Matsushita, Letícia Helena Theodoro, Roberta Okamoto   +8 more
wiley   +1 more source

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba, Péter Ábrányi‐Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Pál Szabó, Gitta Schlosser, Martina Hrast, Stanislav Gobec, Varbina Ivanova, Carles Galdeano, Aleksandra Kopranovic, Marc Neumann, Franz‐Josef Meyer‐Almes, György Miklós Keserű   +18 more
wiley   +1 more source

Molecular Insights and Repellent Efficacy of the Essential Oil and Major Compounds From Piper cyrtopodon (Miq.) C.DC (Piperaceae) Against Aedes aegypti (Linnaeus, 1762) (Culicidae)

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
The essential oil and major compounds from Piper cyrtopodon exhibit potent, long‐lasting repellent activity against Aedes aegypti mosquitoes, combined with low cytotoxicity and favorable molecular docking interactions with odorant‐binding proteins. These findings highlight its potential for the development of alternative products for bite prevention ...
Maria L. L. da Costa, Renata G. de Azevedo, Sergio M. Nunomura, Rita de C. S. Nunomura, Gemilson S. Pontes, Rosemary A. Roque, Tatiane P. de Souza, André C. de Oliveira   +7 more
wiley   +1 more source

Validation and Application of an HPLC–UV Method for the Quantification of 3‐O‐Methylquercetin in Nasal Mucosa

ELECTROPHORESIS, Volume 47, Issue 6, Page 479-488, June 2026.
This study improved an HPLC–UV method for quantifying 3‐O‐methylquercetin in porcine nasal mucosa following ICH M10 and ANVISA (Brazil) guidelines, assessing selectivity, linearity, accuracy, precision, and robustness. The method was applied for the first time to evaluate release, permeation, and retention profiles of a nasal formulation.
Jeniffer Viviana Ramirez Hernández, Laura da Silva Machado, Flávia Nathiely Silveira Fachel, Sara Elis Bianchi, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +6 more
wiley   +1 more source

<b> Assistência farmacêutica como um modelo tecnológico em atenção primária à saúde </b>

Revista de Ciências Farmacêuticas Básica e Aplicada, 2009
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> A Assistência Farmacêutica foi analisada neste artigo, como tecnologia em saúde.
A. L.A. ARAúJO, J. M. UETA, O. FREITAS
doaj  

Quinoa Protein Concentrate as a Platform for the Protection and Controlled Delivery of Resveratrol and Tocopherol

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Graphical abstract illustrating the development of quinoa protein (QP) nanocarriers for the encapsulation of resveratrol (RSV) and tocopherol (TOC). ABSTRACT The objective of this work was to generate and characterize complexes of quinoa proteins (QP) with either resveratrol (RSV) or tocopherol (TOC) whose dimensions fell into the nanoscale.
Alejandra J. Rubinstein, Guadalupe Garcia Liñares, Valeria Boeris, Oscar E. Pérez   +3 more
wiley   +1 more source

Mild and Metal‐Free CH Arylation of Imidazoles via In Situ Diazotization in Water

Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
Imidazoles undergo direct C–H arylation through in situ generated diazonium salts in water, under ambient and catalyst‐free conditions. This operationally simple method avoids hazardous intermediates, tolerates sensitive functional groups, and preserves C–halogen bonds.
Elisabetta Rosadoni, Zefiro Ferraro Fano, Angela Rosa Cuzzola, Fabio Bellina   +3 more
wiley   +1 more source