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Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity

Toxins, 2018
Scorpion venom is a rich source of biologically active components and various peptides with high-potential therapeutic use that have been characterized for their antimicrobial and antiproliferative activities.
Adriana M. S. Parente +13 more
doaj +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino +9 more
wiley +1 more source

Isolation and Characterization of the ‘Flavonoid Crystals’ of Three Species of : Chemotaxonomic Considerations of the Genera and

Natural Product Communications, 2007
The isolation of fragnettin, the so called ‘flavonoid crystals’, from three species of Prosthechea , namely P. fragrans, P. vespa and P. caetensis , and its characterization as 8- C -β-D-quinovopyranosyl apigenin is described.
Jnanabrata Bhattacharyya +4 more
doaj +1 more source

EXCIPIENTES PARA A PRODUÇÃO DE COMPRIMIDOS POR COMPRESSÃO DIRETA

Infarma: Pharmaceutical Sciences, 2013
O interesse da indústria farmacêutica na produção de comprimidos através da compressão direta tem aumentado nos últimos anos, principalmente por ser um método de produção de fácil controle e com menor tempo de processo, levando a uma maior produtividade ...
Tiago Rafael SAUSEN, Paulo MAYORGA
doaj +1 more source

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado +9 more
wiley +1 more source

Biological Effects of Selenium‐Containing Ionic Liquids: Cytotoxicity, Mercury Interaction, and Antiproliferative Activity in Glioblastoma Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder +17 more
wiley +1 more source

Comprehensive preclinical studies on the bioactivity of Orbignya phalerata Mart. (Babassu) and its derived products: a systematic review

Future Journal of Pharmaceutical Sciences
Background Babassu (Orbignya phalerata Mart.) is a palm tree well distributed in Latin America, whose fruit has a mesocarp and kernel used for human feeding, and empirically related to the treatment of gastritis, vaginitis, and wound healing.
Nicole Debia +6 more
doaj +1 more source

Chemistry and Health: A Multidimensional Approach

Sustainable Chemistry
This review explores both the positive and negative impacts of chemistry on society, focusing on the intersection between pharmaceutical, natural, and synthetic chemicals.
Alcione S. de Carvalho +6 more
doaj +1 more source

Oportunidades na indústria de medicamentos e a lógica do desenvolvimento local baseado nos biomas brasileiros: bases para a discussão de uma política nacional [PDF]

Cadernos de Saúde Pública, 2007
Este trabalho traz para a Saúde Pública a discussão de novos conceitos sobre o desenvolvimento tecnológico de medicamentos de origem vegetal, constatando as oportunidades no mercado da indústria farmacêutica tanto para a produção de medicamentos ...
Glauco de Kruse Villas Bôas, Carlos Augusto Grabois Gadelha +1 more
doaj

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil +7 more
wiley +1 more source

medicinal chemistry
biotechnology