Results 11 to 20 of about 1,904 (138)

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

Mediators of Inflammation, 2011
Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos, Jacqueline Alves Leite, Luciana Teles Carneiro, Márcia Regina Piuvezam, Maria Raquel Vitorino de Lima, Liana Clébia Lima de Morais, Vivian Mary Rumjanek, Sandra Rodrigues-Mascarenhas   +7 more
doaj   +1 more source

Karaya/Gellan-Gum-Based Bilayer Films Containing 3,3′-Diindolylmethane-Loaded Nanocapsules: A Promising Alternative to Melanoma Topical Treatment

Pharmaceutics, 2023
This study aimed to incorporate nanocapsules containing 3,3′-diindolylmethane (DIM) with antitumor activity into a bilayer film of karaya and gellan gums for use in topical melanoma therapy.
Jéssica Brandão Reolon, Camila Parcianello Saccol, Bárbara Felin Osmari, Daiane Britto de Oliveira, Vinicius Costa Prado, Fernanda Licker Cabral, Lucas Saldanha da Rosa, Giancarlo Cervo Rechia, Daniela Bitencourt Rosa Leal, Letícia Cruz   +9 more
doaj   +1 more source

Anticonvulsant Activity of the Linalool Enantiomers and Racemate: Investigation of Chiral Influence

Natural Product Communications, 2010
The anticonvulsant activity of the racemate and enantiomers of linalool have been evaluated. Pretreatment of the mice with ( S )-(+)-, ( R )-(-)- and rac -linalool increased the latency of convulsions significantly in the PTZ model.
Damião P. de Sousa, Franklin F. F. Nóbrega, Camila C. M. P. Santos, Reinaldo N. de Almeida   +3 more
doaj   +1 more source

Equilíbrio, estratégia competitiva e inovação: um estudo descritivo de casos

Gestão e Desenvolvimento, 2015
Uma forma altamente simplista de explicar o funcionamento das organizações no mercado é dizer que estas oferecem produtos e/ou serviços de acordo com as necessidades do mercado de forma lucrativa.
Cícero Eduardo Walter, Rafael Leite, Liliana Craveiro   +2 more
doaj   +1 more source

Constituents of ‘Caincin’, a Bioactive Saponin Fraction from the Root-bark of (L.) Hitch

Natural Product Communications, 2008
‘Caincin’, a bioactive saponin mixture from Chiococca alba (L.) Hitch. (Rubiaceae), first obtained by European workers in nineteenth century and which was thought to be a homogenous material, was investigated by us and resulted in the isolation of three ...
Jnanabrata Bhattacharyya, S. K. Srivastava, M. F. Agra, George Majetich   +3 more
doaj   +1 more source

Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging

Molecules, 2020
Antioxidants have long been used in the cosmetic industry to prevent skin photoaging, which is mediated by oxidative stress, making the search for new antioxidant compounds highly desirable in this field.
Diana I. S. P. Resende, Mariana C. Almeida, Bruna Maciel, Helena Carmo, José Sousa Lobo, Carlotta Dal Pozzo, Sara M. Cravo, Gonçalo P. Rosa, Aida Kane-Pagès, Maria do Carmo Barreto, Isabel F Almeida, Maria Emília de Sousa, Madalena M. M. Pinto   +12 more
doaj   +1 more source

Development of a Method for the Quantification of Clotrimazole and Itraconazole and Study of Their Stability in a New Microemulsion for the Treatment of Sporotrichosis

Molecules, 2019
Sporotrichosis occurs worldwide and is caused by the fungus Sporothrix brasiliensis. This agent has a high zoonotic potential and is transmitted mainly by bites and scratches from infected felines.
Patricia Garcia Ferreira, Carolina Guimarães de Souza Lima, Letícia Lorena Noronha, Marcela Cristina de Moraes, Fernando de Carvalho da Silva, Alessandra Lifsitch Viçosa, Débora Omena Futuro, Vitor Francisco Ferreira   +7 more
doaj   +1 more source

Influence of grape seed oil on sun protection factor in sunscreen formulations: a study using Central Composite Design approach

Drug Analytical Research, 2022
This study aimed to evaluate the influence of the grape seed oil (GSO) on the sun protection factor (SPF) of sunscreen emulsified formulations containing butyl methoxydibenzoylmethane (avobenzone (AVO)) and octyl methoxycinnamate (OMC) developed by ...
Paola de Souza Sanches, Laila Michalski de Oliveira Peixoto, Thamyres Conti dos Santos, Carina Quintanilha da Silva, Gabriela Baptista Brito, Yasmim da Silva Flores, Natália Farias Santos, Emeli Moura de Araújo, Samanta Cardozo Mourão, Deborah Quintanilha Falcão   +9 more
doaj   +1 more source

Análise do novo marco regulatório de insumos farmacêuticos ativos no Brasil: a experiência de um laboratório farmacêutico oficial

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2023
Introdução: O novo marco regulatório de insumos farmacêuticos ativos compreende três resoluções editadas pela Agência Nacional de Vigilância Sanitária em 2020, RDC nº 359, RDC nº 361 e RDC nº 672, inaugurando novas abordagens para regularização do ...
Soraya Mileti da Costa, Maria Helena Simões Villas Boas, Priscila da Nobrega Rito   +2 more
doaj   +1 more source

Characterization of nimesulide and development of immediate release tablets

Eclética Química, 2019
To characterize nimesulide raw materials from different manufacturers and to develop immediate release tablets, in order to register a generic product.
Helvécio Vinícius Antunes Rocha, Rachel de Sousa Augusto, Livia Deris Prado, Erika Martins de Carvalho   +3 more
doaj   +1 more source