Results 31 to 40 of about 793,369 (298)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
To be or not to be, the importance of Digital Identity in the networked society [PDF]
, 2011 The emergence of the web has had a deep impact at different levels of our society, changing the way people connect, interact, share information, learn and work.
Costa, Cristina, Torres, Ricardo
core +1 more source
A domótica ao serviço da sociedade [PDF]
, 2008 Com a elevada evolução dos sistemas electrónicos e computacionais, associados a tecnologias de comunicação cada vez mais evoluídas, alcançou-se um novo domínio de aplicação tecnológica que tem por objectivo satisfazer as cada vez maiores necessidades
Brandão, Roque Filipe Mesquita
core +2 more sources
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Novos paradigmas na educacão online com a aprendizagem aberta [PDF]
, 2007 This paper aims to discuss important concepts related to online education which bring a new educational paradigm: open learning through free learning materials and technologies.
Okada, Alexandra
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A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Tecnologias Disruptivas e Tecnologias Educativas
Revista Brasileira de Aprendizagem Aberta e a DistânciaJá é consolidado e de senso comum que as Tecnologias Digitais de Informação, Comunicação e Expressão (TICE) e outras tecnologias disruptivas impactam irreversivelmente todas as modalidades de ensino. No âmbito da Educação Profissional e Tecnológica, a adoção de novos modos de formação em resposta a esses impactos torna-se uma necessidade premente ...
openaire +2 more sources
Advanced Engineering Materials, EarlyView.Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni +7 more
wiley +1 more source
Novas Tecnologias e Saúde [PDF]
, 2014 Introdução Comecemos por algo simples: lidar e combater doenças sempre pressupõe alguma forma de domínio técnico, mesmo quando as práticas para obtenção da saúde estão culturalmente associadas a meios mágicos. Um aspecto importante da magia, seu sentido
Jonatas Ferreira +1 more
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Advanced Functional Materials, EarlyView.This work demonstrates the successful integration of a phenanthroline‐based 2D COF with MnI catalytic sites into a catholyte‐free membrane‐electrode‐assembly cell for CO2 electroreduction. The crystalline COF actively suppresses Mn⁰–Mn⁰ dimerization, achieving a turnover frequency of 617 h⁻¹ at 2.8 V (full‐cell potential), and enabling stable operation.
Laura Spies +8 more
wiley +1 more source