Results 51 to 60 of about 1,158 (177)

Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey

Nutrition in Clinical Practice, EarlyView.
Abstract Background Short bowel syndrome is a debilitating condition often requiring long‐term parenteral support to maintain hydration, nutrition, and survival. Methods As part of the noninterventional, cross‐sectional Landmark Survey study, we evaluated burdens associated with short bowel syndrome and parenteral support dependency from patient and ...
Jenny E. Harrison, Syed‐Mohammed Jafri, Roopa Vemulapalli, Vanessa Kumpf, Gail Mitchell, Mena Boules, Mindy M. Yang, Laurin Jackson, Jinyi Wang, Laurie Zografos, Daniel Wolin, Marion F. Winkler   +11 more
wiley   +1 more source

The real-world analysis of adverse events with teduglutide: a pharmacovigilance study based on the FAERS database

Frontiers in Pharmacology
BackgroundTeduglutide, the first glucagon-like peptide 2 analogue, has been demonstrated to facilitate the absorption of gut nutrient and lessen the need for parenteral assistance in patients with Short Bowel Syndrome (SBS).
Xiaogan Wang, Xiaogan Wang, Hao Chen, Hao Chen, Shuangshuang Han, Shuangshuang Han, Lingbo Li, Lingbo Li, Hongjin Chen, Bolin Yang   +9 more
doaj   +1 more source

Disordered pancreatic and gastrointestinal hormone responses to nutrient stimulation in Zambian children with severe acute malnutrition

Experimental Physiology, Volume 111, Issue 10, Page 4552-4564, 1 October 2026.
Abstract Nutrient sensing enables the body to detect and respond to nutrient availability through hormonal regulation. In this study, we examined nutrient‐stimulated hormonal responses in children with severe acute malnutrition (SAM) compared with hospitalized (HC) and community (CC) child comparators.
Ellen Besa, Ruth Phiri, Andreck Tembo, Gwen Nayame, Amon Ngongola, Jens Rehfeld, Bolette Hartmann, Gary Frost, Douglas C. Heimburger, Paul Kelly   +9 more
wiley   +1 more source

Teduglutide: a review of its use in short bowel syndrome

, 2016
Introducción: la nutrición parenteral (NP) a largo plazo puede asociarse a complicaciones graves, con un deterioro importante de la calidad de vida de los pacientes con síndrome de intestino corto (SIC).
Moreno Villares, José Manuel, Burgos Peláez, Rosa, Mauri Roca, Sílvia, García Luna, Pedro Pablo, Virgili Casas, M. Nuria, Wanden-Berghe, Carmina, Martínez Faedo, Ceferino, Cuerda Compes, M. Cristina   +7 more
core   +1 more source

Retrospective study of the effectiveness and safety of teduglutide in short bowel syndrome adult patients. The T-Rex study

Clinical Nutrition Open Science
Background: Clinical management of chronic intestinal failure associated with short bowel syndrome (SBS–CIF) focuses on providing nutritional support and alleviating the symptoms.
Yaiza García Delgado, María Maiz, José Joaquín Alfaro, Coral Montalbán, Ainhoa Oguiza, Jesús Aparicio, Carmen Montoto-Otero, Nuria Virgili   +7 more
doaj   +1 more source

GLP2-GLP2R signal affects the viability and EGFR-TKIs sensitivity of PC9 and HCC827 cells

BMC Pulmonary Medicine, 2022
Background The resistance to epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKIs) therapy is currently the major clinical challenge in the treatment of lung cancer. This study aims to reveal the role of glucagon-like peptide (GLP) 2
Bin Song, Hong Ge, Chenwei Pu, Ning Li
doaj   +1 more source

Exploring the disease burden and quality of life in patients with short bowel syndrome with intestinal failure: Insights from exit interviews in the glepaglutide EASE SBS‐1 phase 3 trial

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1106-1118, August 2026.
Abstract Background A randomized, double‐blind, placebo‐controlled trial was conducted to evaluate efficacy and safety of glepaglutide in patients who have short bowel syndrome with intestinal failure (SBS‐IF). At the end of the trial, exit interviews were conducted to explore participants' experiences and to assess the impact of the disease and ...
David F. Mercer, Constance Mubekapi‐Musadaidzwa, Bitten Kloster, Mark Berner‐Hansen, Anna Rydén, Palle Bekker Jeppesen   +5 more
wiley   +1 more source

GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR SignalingSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Glucagon-like peptide (GLP)-2 may exert antifibrotic effects on hepatic stellate cells (HSCs). Thus, we aimed to test whether application of the GLP-2 analogue teduglutide has hepatoprotective and antifibrotic effects in the Mdr2 ...
Claudia D. Fuchs, Thierry Claudel, Veronika Mlitz, Alessandra Riva, Moritz Menz, Ksenia Brusilovskaya, Felix Haller, Maximilian Baumgartner, Philipp Königshofer, Lukas W. Unger, Wilhelm Sjöland, Hubert Scharnagl, Tatjana Stojakovic, Georg Busslinger, Thomas Reiberger, Hanns-Ulrich Marschall, Michael Trauner   +16 more
doaj   +1 more source

Chronic, but not acute, treatment with GLP‐2 and GIP in combination increases glucose absorption in the isolated vascularly perfused rat intestine

Physiological Reports, Volume 14, Issue 16, August 2026.
Chronic GLP‐2 + GIP treatment increases glucose absorption. Abstract The gut hormones, glucagon‐like peptide‐2 (GLP‐2) and glucose‐dependent insulinotropic polypeptide (GIP), may be important regulators of intestinal nutrient absorption. Using the isolated vascularly perfused rat intestine of male rats, we investigated the chronic and subacute ...
Katrine D. Galsgaard, Tyler A. Cookson, Ida M. Modvig, Valentina Abba, Samuel A. J. Trammell, Mette M. Rosenkilde, Lærke S. Gasbjerg, Charlotte M. Sørensen, Bolette Hartmann, Jens J. Holst   +9 more
wiley   +1 more source

Safety and Efficacy of Teduglutide in Pediatric Patients With Intestinal Failure due to Short Bowel Syndrome : A 24-Week, Phase III Study [PDF]

, 2020
Background This study evaluated the safety and efficacy of teduglutide in pediatric patients with short bowel syndrome-associated intestinal failure (SBS-IF).
Protheroe, Susan, Andrew A. Grimm, Hu, Simin, Grimm, Andrew A., Russell J. Merritt, Samuel A. Kocoshis, Mikko P. Pakarinen, Carter, Beth A., Venick, Robert S., Pakarinen, Mikko P., Simin Hu, Horslen, Simon, Beth A. Carter, Mercer, David F., Merritt, Russell J., Simon Horslen, Robert S. Venick, Hill, Susan, Kaufman, Stuart S., Kocoshis, Samuel A., Susan Protheroe, David F. Mercer, Susan Hill, Paul W. Wales, Wales, Paul W., Stuart S. Kaufman   +25 more
core   +1 more source