Results 131 to 140 of about 24,923 (301)

Long-term monitoring of TEER in Calu-3 cell monolayers.

, 2016
The measurements were performed in a Transwell cluster with six inserts (W1–W6, W1 was devoid of cells, acting as a reference). At each time point, the values are individual TEER measurements from the three ports of each insert.
Hao Xu (6530), Hjalmar Brismar (40442), Marina Zelenina (2512255), Ying Fu (173963), Aizat Turdalieva (2512252), Hans Blom (456800), Johan Solandt (2512258), Nestan Shambetova (2512249)   +7 more
core   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Stuck in the Traffic-Light: Moving Past Color Signals to Real Decisions in Mitral Transcatheter Edge-to-Edge Therapy Management

Structural Heart
Historically, the complexity of patients being evaluated for mitral transcatheter edge-to-edge therapy (M-TEER) has been divided into 3 main categories: green zone: defined as cases where M-TEER is straightforward and not complex, yellow zone: cases with
Vratika Agarwal, MD, Firas Zahr, MD
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Transepithelial Electrical Resistance (TEER) measurement. Virtual Lab video

, 2021
Transepithelial Electrical Resistance (TEER) measurement. Virtual Lab video.FCT/MCTES através de fundos nacionais (PIDDAC), PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017 e ToxOmics (UIDB/00009/2020; UIDP/00009/2020, FCT).N/
Rolo, Dora, Ventura, Célia, Pinto, Fátima, Vital, Nádia, Moreira, Rodrigo, Cadete, João, Louro, Henriqueta, Silva, Maria João   +7 more
core  

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Quality of life after transcatheter tricuspid valve repair: results from the Tri.FR trial

ESC Heart Failure
Aims In the Tri.FR trial, tricuspid transcatheter edge‐to‐edge repair (T‐TEER) reduced severity of tricuspid regurgitation (TR) and improved the composite clinical score, driven by patient‐reported outcomes.
Sabina Istratoaie, Pascal deGroote, Nicole Karam, Jean‐Noel Trochu, Guillaume Leurent, Augustin Coisne, Pierre‐Yves Le Roux, Anne Ganivet, Anne Bernard, Antoinette Neylon, Romain Pierrard, Florent Le Ven, François Picard, Nicolas Piriou, Thierry Laperche, Jerome Jouan, Amedeo Anselmi, Vincent Auffret, Emmanuel Oger, Erwan Donal   +19 more
doaj   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source