Results 251 to 260 of about 72,827 (301)

Dyskerin dysfunction in cancer development: from telomere dysregulation to immune deficiency. [PDF]

Am J Cancer Res
Xie Y, Xue N, Xue L, Zeng X, Wang J, Zhang X.   +5 more
europepmc   +1 more source

Construction of TERT Monoallelic Knockout and TERT Overexpression of Porcine Cell Lines and Study of the Cellular Biological Characteristics. [PDF]

Animals (Basel)
Yang Y, Chen X, Wang J, Xiong J, Zhang X, Wang J, Xu W, Qing Y, Li H, Zhao HY.   +9 more
europepmc   +1 more source

Control of telomerase recruitment and end protection by independent shelterin components. [PDF]

Nat Commun
Sandhu R, Tricola GM, Lee SY, Tran A, Lazzerini Denchi E.   +4 more
europepmc   +1 more source

A Systematic Review of Telomere Length and Telomerase Activity in Preeclampsia: Maternal, Placental, and Cord Blood Perspectives. [PDF]

Med Sci (Basel)
Gerede A, Oikonomou E, Chatzakis C, Stavros S, Danavasi M, Potiris A, Anagnostaki I, Karampitsakos T, Theofanakis C, Domali E, Sotiriadis A.   +10 more
europepmc   +1 more source

SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres. [PDF]

Neuro Oncol
Brown A, Strickland LM, Erman EN, Pirozzi CJ, Low JT, Diplas BH, Gibson E, Shobande M, Khambati T, Krylova M, Liu H, McLendon RE, Reitman ZJ, Keir ST, Zou L, Ashley DM, Waitkus MS.   +16 more
europepmc   +1 more source

Shelterin Component TPP1 Drives Tumor Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma. [PDF]

Biomedicines
Jang JE, Kim HS, Kim JS, Han JM, Cho HS, Tak KY, Han JW, Sung PS, Bae SH, Jang JW.   +9 more
europepmc   +1 more source

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Telomerase

Der Hautarzt, 1997
Telomerase is an enzyme that elongates telomeric repeats, the specialized structures at the ends of chromosomes that provide genomic stability and compensate for the physiologic process of telomere shortening. It has been implicated in cellular senescence, immortalization, and carcinogenesis.
J, Lübbe, H, Nakazawa, G, Burg
openaire   +2 more sources

Telomerases

Current Opinion in Structural Biology, 1999
Telomerases are RNA-dependent polymerases that catalyse the synthesis of the telomeric DNA at the tips of eukaryotic chromosomes. The recent identification of the catalytic subunit of telomerases from several different species suggests that the core of the telomerase is conserved.
M, O'Reilly, S A, Teichmann, D, Rhodes
openaire   +2 more sources

Telomerase, Telomerase Inhibition, and Cancer

Journal of Anti-Aging Medicine, 2003
Telomeres, located at the ends of eukaryotic chromosomes, are synthesized by the enzyme telomerase and are responsible for maintaining chromosome length. The absence of telomerase in most somatic cells has been associated with telomere shortening and aging of these cells. In contrast, high levels of telomerase activity are observed in over 90% of human
Ali, Ahmed, Trygve O, Tollefsbol
openaire   +2 more sources