Results 141 to 150 of about 85,495 (318)
Loss of telomere protection: consequences and opportunities.
Frontiers in Oncology, 2013 Telomeres are repetitive sequences at the natural ends of linear eukaryotic chromosomes that protect these from recognition as chromosome breaks. Their ability to do so critically depends on the binding of sufficient quantities of functional shelterin, a
Jacqueline Johanna Leonarda Jacobs
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Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b [PDF]
, 2018 Katja Kratz, Titia de Lange
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Structurally distinct telomere-binding proteins in Ustilago maydis execute non-overlapping functions in telomere replication, recombination, and protection [PDF]
, 2020 Eun Young Yu +6 more
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Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms
British Journal of Pharmacology, EarlyView.The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl +3 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman +10 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
G-quadruplex recognition by the yeast telomere binding protein Rap1 [PDF]
, 2019 Although biochemical and structural studies have shown that DNA can adopt various conformations other than the canonical right – handed double helix, such structures were thought to be in vitro artifacts. It has been known for decades, that single stranded guanine – rich DNA can fold into a structure called G – quadruplexes. Those structures arise from
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International Journal of Cosmetic Science, EarlyView.Microalgae extracts show immense potential in cosmetics for their bioactivities; emerging extraction techniques enhance bioactive compound yield from microalgae. Abstract Microalgae have attracted significant interest in numerous sectors, particularly in the cosmetic industries, owing to their rich composition of bioactive compounds. This paper aims to
Alireza Mousakhani Ganjeh +5 more
wiley +1 more source
Clinical Significance of Telomere Length and Associated Proteins in Oral Cancer
Biomarker Insights, 2007 Purpose: Telomere shortening is an important event during carcinogenesis. Although studies suggest role of multiple proteins in telomere length regulation, there is dearth of reports in oral cancer which is a leading malignancy in Asian countries ...
Rachana N. Sainger +3 more
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Exploring TRF2-Dependent DNA Distortion Through Single-DNA Manipulation Studies
Communications BiologyTRF2 is a component of shelterin, a telomere-specific protein complex that protects the ends of mammalian chromosomes from DNA damage signaling and improper repair.
Xiaodan Zhao +6 more
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