Results 81 to 90 of about 85,495 (318)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis. [PDF]

PLoS Genetics, 2014
Protection of Telomeres 1 (POT1) is a conserved nucleic acid binding protein implicated in both telomere replication and chromosome end protection. We previously showed that Arabidopsis thaliana POT1a associates with the TER1 telomerase RNP, and is ...
Kyle B Renfrew, Xiangyu Song, Jung Ro Lee, Amit Arora, Dorothy E Shippen   +4 more
doaj   +1 more source

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]

, 2017
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao, Deng, Wuguo, Fu, Xiaoyan, Gao, Fan, Huang, Wenlin, Kang, Lan, Li, Wenbin, Li, Yixin, Liu, Tianze, Qin, Ge, Shi, Dingbo, Shi, Fen, Song, Chen, Tang, Bing, Tang, Ranran, Wu, Xiaojun, Xiao, Binyi, Xiao, Xiangsheng, Zhang, Changlin   +18 more
core   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

A persistent variant telomere sequence in a human pedigree

Nature Communications
The telomere sequence, TTAGGG, is conserved across all vertebrates and plays an essential role in suppressing the DNA damage response by binding a set of proteins termed shelterin. Changes in the telomere sequence impair shelterin binding, initiate a DNA
Angela M. Hinchie, Samantha L. Sanford, Kelly E. Loughridge, Rachel M. Sutton, Anishka H. Parikh, Agustin A. Gil Silva, Daniel I. Sullivan, Pattra Chun-On, Matthew R. Morrell, John F. McDyer, Patricia L. Opresko, Jonathan K. Alder   +11 more
doaj   +1 more source

The role of Rif1 in telomere length regulation is separable from its role in origin firing

eLife, 2020
To examine the established link between DNA replication and telomere length, we tested whether firing of telomeric origins would cause telomere lengthening.
Calla B Shubin, Carol W Greider
doaj   +1 more source

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.

PLoS Genetics, 2022
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders.
Amanda J Stock, Ross A McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G Becker, Elin Lehrmann, William H Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu   +18 more
doaj   +1 more source

Processing of G4 DNA by Dna2 Helicase/nuclease and RPA provides insights into the mechanism of Dna2/RPA substrate recognition [PDF]

, 2008
The polyguanine-rich DNA sequences commonly found at telomeres and in rDNA arrays have been shown to assemble into structures known as G quadruplexes, or G4 DNA, stabilized by base-stacked G quartets, an arrangement of four hydrogen-bonded guanines.
Campbell, Judith L., Chen, Lu, Masuda-Sasa, Taro, Peng, Xiao P., Polaczek, Piotr   +4 more
core  

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. [PDF]

, 2018
To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to ...
Allen, Denise, Chronis, Contantinos, Cinkornpumin, Jessica, Fu, Kai, Germanguz, Igal, Korsakova, Elena, Kuoy, Edward, Langerman, Justin, Lee, Peiyee, Lowry, William E, Ohashi, Minori, Park, Jenny C, Pellegrini, Matteo, Plath, Kathrin, Salas, Carlos, Tran, Stephen, Vargas, Benni S, Xiao, Xinshu   +17 more
core   +2 more sources

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox [PDF]

, 2020
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to ...
Almeida, Sérgio F. de, Huertas Sánchez, Pablo, Legube, Gaëlle, Vítor, Alexandra C.   +3 more
core   +4 more sources