Results 271 to 280 of about 110,933 (294)
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Experimental Gerontology, 2007
The extent and potential significance of telomere erosion, as a function of age in human tissues, is becoming increasingly apparent. In this, the second yearly review on telomeres and ageing, I review a small selection of papers published between July 2006 and June 2007.
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The extent and potential significance of telomere erosion, as a function of age in human tissues, is becoming increasingly apparent. In this, the second yearly review on telomeres and ageing, I review a small selection of papers published between July 2006 and June 2007.
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Telomeres in evolution and evolution of telomeres
Chromosome Research, 2005This paper examines telomeres from an evolutionary perspective. In the monocot plant order Asparagales two evolutionary switch-points in telomere sequence are known. The first occurred when the Arabidopsis-type telomere was replaced by a telomere based on a repeat motif more typical of vertebrates. The replacement is associated with telomerase activity,
Jirí, Fajkus +2 more
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The Journal of Pathology, 2009
AbstractTelomeres, the ends of eukaryotic chromosomes, have been the subject of intense investigation over the last decade. As telomere dysfunction has been associated with ageing and developing cancer, understanding the exact mechanisms regulating telomere structure and function is essential for the prevention and treatment of human cancers and age ...
De Boeck, Gitte +3 more
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AbstractTelomeres, the ends of eukaryotic chromosomes, have been the subject of intense investigation over the last decade. As telomere dysfunction has been associated with ageing and developing cancer, understanding the exact mechanisms regulating telomere structure and function is essential for the prevention and treatment of human cancers and age ...
De Boeck, Gitte +3 more
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Science, 1998
Cells are equipped with surveillance mechanisms that carefully scan the DNA for breaks and repair any that are found. So what happens when this quality control apparatus comes upon the end of the chromosome, the telomere? An ill-placed repair at this position will join two chromosomes together or, worse, join the end of one chromosome to internal ...
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Cells are equipped with surveillance mechanisms that carefully scan the DNA for breaks and repair any that are found. So what happens when this quality control apparatus comes upon the end of the chromosome, the telomere? An ill-placed repair at this position will join two chromosomes together or, worse, join the end of one chromosome to internal ...
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Telomere uncapping and alternative lengthening of telomeres
Mechanisms of Ageing and Development, 2008A substantial number of human tumors utilize a telomerase-independent telomere length maintenance mechanism referred to as alternative lengthening of telomeres (ALT). Although it is known that ALT is a telomere-specific, loss of function phenotype, which involves lengthening of telomeres by homologous recombination-mediated replication of telomeric DNA,
Anthony J, Cesare, Roger R, Reddel
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Current Opinion in Cell Biology, 1992
Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telomeres perform their various roles in ...
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Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telomeres perform their various roles in ...
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Annual Review of Biochemistry, 1996
Telomeres are the components of chromosome ends that provide stability and allow the complete replication of the ends. Telomere length is maintained by a balance between processes that lengthen and those that shorten telomeres. Telomeraseis a ribonucleoprotein polymerase that specifically elongates telomeres.
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Telomeres are the components of chromosome ends that provide stability and allow the complete replication of the ends. Telomere length is maintained by a balance between processes that lengthen and those that shorten telomeres. Telomeraseis a ribonucleoprotein polymerase that specifically elongates telomeres.
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Human Telomeres and Telomere Biology Disorders
2014Telomeres consist of long nucleotide repeats and a protein complex at chromosome ends essential for chromosome stability. Telomeres shorten with each cell division and thus are markers of cellular age. Dyskeratosis congenita (DC) is a cancer-prone inherited bone marrow failure syndrome caused by germ-line mutations in key telomere biology genes that ...
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The Ruminant Telomere-to-Telomere (RT2T) Consortium
Nature GeneticsTelomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies ...
Kalbfleisch, Theodore +77 more
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2015
Telomeres are specialised structures that protect chromosome ends from degradation and fusion events. In most eukaryotes, including yeast and mammals, telomeric DNA consists of short, repetitive G‐rich sequences, which end with 3′ G‐rich overhangs and are elongated by the specialised reverse transcriptase telomerase.
RAFFA, GRAZIA DANIELA, CENCI, GIOVANNI
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Telomeres are specialised structures that protect chromosome ends from degradation and fusion events. In most eukaryotes, including yeast and mammals, telomeric DNA consists of short, repetitive G‐rich sequences, which end with 3′ G‐rich overhangs and are elongated by the specialised reverse transcriptase telomerase.
RAFFA, GRAZIA DANIELA, CENCI, GIOVANNI
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