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Telomere length predicts cardiovascular disease
BMJ, 2014Measurement in humans is unlikely to be useful until we find out how and why Atherosclerosis is an age related disease characterised by systemic oxidative stress and low grade chronic inflammation. Telomeres consist of DNA repeats at the ends of chromosomes, which shorten with every cell division.
Ioakim, Spyridopoulos +1 more
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Recombination in telomere-length maintenance
Trends in Biochemical Sciences, 2000Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion.
A, Kass-Eisler, C W, Greider
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Telomere length inheritance and aging
Mechanisms of Ageing and Development, 2008Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of ...
Dennis, Kappei +1 more
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Telomere length and telomere-centromere relationships?
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998The quantitative fluorescence in situ hybridization (Q-FISH) technique enables an accurate estimate of individual telomere lengths, a possibility beyond the resolution of conventional techniques. So far, Q-FISH has been used for the estimate of individual telomere lengths in human, mouse and Chinese hamster chromosomes.
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Childhood Adversity and Telomere Length
Biological Research For NursingPurpose: Exposure to adversity during childhood and adolescence is associated with numerous health conditions in adulthood; telomere shortening may be a mechanism through which adversity contributes to poor outcomes. We studied three areas of adversity (parent relational instability, child household instability, and financial instability) occurring ...
Rita H. Pickler +5 more
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Telomere length in Hepatitis C
Cancer Genetics and Cytogenetics, 2008Telomeres are nucleoprotein structures located at the termini of chromosomes that protect the chromosomes from fusion and degradation. Hepatocyte cell-cycle turnover may be a primary mechanism of telomere shortening in hepatitis C virus (HCV) infection, inducing fibrosis and cellular senescence. HCV infection has been recognized as potential cause of B-
Y, Kitay-Cohen +4 more
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Diet, nutrition and telomere length
The Journal of Nutritional Biochemistry, 2011The ends of human chromosomes are protected by DNA-protein complexes termed telomeres, which prevent the chromosomes from fusing with each other and from being recognized as a double-strand break by DNA repair proteins. Due to the incomplete replication of linear chromosomes by DNA polymerase, telomeric DNA shortens with repeated cell divisions until ...
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Haploinsufficiency and telomere length homeostasis
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012In humans, autosomal dominant or X-linked disease can arise through a phenomenon termed haploinsufficiency, where one remaining wild-type allele is insufficient for function. In model organisms, the impact of heterozygosity can be tested directly with engineered mutant alleles or in a hemizygous state where the expression of one allele is abrogated ...
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Fatty acids and telomere length
Current Opinion in Clinical Nutrition & Metabolic CarePurpose of review This narrative review includes the latest clinical and preclinical evidence on fatty acid exposure and telomere length, a widely accepted hallmark of aging. Recent findings A large body of literature focused on n-3 (omega-3) polyunsaturated fatty acids (PUFAs ...
Marta, Crous-Bou +3 more
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