Results 61 to 70 of about 10,528,536 (309)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Study on Positive Temperature Effect of Moderator in TOPAZ-Ⅱ Reactor
Yuanzineng kexue jishu, 2023 TOPAZ-Ⅱ space nuclear reactor power supply adopts thermionic static thermoelectric conversion mode, the output power of the system is 5 kW, and its service life can reach 3 years. It is one of the most advanced space nuclear power supply systems that can
SHI Yunda;SUN Zheng;YANG Rui;HU Binhe;AN Weijian;ZHAO Shouzhi
doaj
, 2014 Citation: 'temperature coefficient' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.T06262 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Coefficients of Linear Expansion at Low Temperatures [PDF]
Physical Review (Series I), 1905 1 p.l., [88]-102, 10 p.
Ayres, H. H., Dorsey, Herbert Grove 1876
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Sensors, 2019 The strain of fiber-reinforced polymer (FRP) bars at high temperatures is currently difficult to measure. To overcome this difficulty, a method of smart FRP bars embedded with optical fibers was proposed and studied, in which an ordinary single-mode ...
Jiahui Shen +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A 3.0-V, High-Precision, High-PSRR BGR with High-Order Compensation and Improved FVF Pre-Regulation
MicromachinesA 3.0 V bandgap reference (BGR) for battery management integrated circuit (BMIC) is presented, achieving a low temperature coefficient (TC) and a high power supply rejection ratio (PSRR).
Yongkang Shen +7 more
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