Results 41 to 50 of about 671,184 (266)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of temperature on optical properties of thin films Cu2ZnSnSe4

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2018
The use of solar cells in various fields of science and technology contributes to the development of materials science and scientific activity in this area.
E. V. Maystruk, I. P. Koziarskyi, D. P. Koziarskyi, P. D. Maryanchuk   +3 more
doaj   +1 more source

The Dependence of Ultrasonic Velocity in Ultra-Low Expansion Glass on Temperature

Applied Sciences, 2022
The coefficient of thermal expansion (CTE) is an important property of ultra-low expansion (ULE) glass, and the ultrasonic velocity method has shown excellent performance for the nondestructive measurement of CTE in large ULE glass.
Wenqing Wei, Yongfeng Zhang, Zongzheng Du, Minwei Song, Yuanyuan Zhang, Hong Liu   +5 more
doaj   +1 more source

Finite Temperature Chern-Simons Coefficient [PDF]

Physical Review Letters, 1997
Summary: We compute the exact finite temperature effective action in a \((0 + 1)\)-dimensional field theory containing a topological Chern-Simons term, which has many features in common with \((2 + 1)\)-dimensional Chern-Simons theories. This exact result explains the origin and meaning of puzzling temperature dependent coefficients found in various ...
Dunne, Gerald, Lee, Kimyeong, Lu, Changhai   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Analysis of the Relationship Between Photovoltaic Temperature Coefficients and Varying Solar Irradiance Levels

Revue des Énergies Renouvelables
This work presents an experimental investigation into the temperature coefficients of aged monocrystalline photovoltaic (PV) modules operating under real outdoor conditions. The analysis is based on one year of high-resolution monitoring data from a grid-
Nasreddine Belhaouas, Hichem Hafdaoui, Fatah Mehareb, Bilal Taghezouit, Houria Assem, Nadira Madjoudj, Amina Chahtou, Djohra Saheb-Koussa   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Energy performance of commercial c-Si PV modules in accordance with IEC 61853-1, -2 and impact on the annual specific yield

EPJ Photovoltaics, 2023
As energy yields of photovoltaic modules are highly related to local climate and ambient conditions, it is necessary to assess the energy-yield performance of PV modules under various operating conditions.
Monokroussos Christos, Zhang Yating, Lee Eleanor W., Xu Frank, Zhou Allen, Zhang Yichi, Herrmann Werner   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A 2V, 32.13nA, fully MOSFET Voltage Limiter for Low Power Applications [PDF]

Radioengineering, 2022
This paper presents a fully MOSFET DC voltage limiter with low current consumption. In the proposed voltage reference structure to reduce power consumption, transistors are biased in the sub-threshold region.
H. Rayat, R. Dastanian
doaj