Results 91 to 100 of about 13,706,361 (339)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tree growth at the limits: the response of multiple conifers to opposing climatic constraints along an elevational gradient in the Alps

Frontiers in Forests and Global Change
IntroductionClimate change affects the vitality of mountain forests through increasing temperatures and decreasing water availability due to changing precipitation patterns, earlier snowmelt, and increasing evaporative demand.
Nikolaus Obojes, Serena Buscarini, Armin Konrad Meurer, Erich Tasser, Walter Oberhuber, Stefan Mayr, Ulrike Tappeiner, Ulrike Tappeiner   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of Oil and Solid Body Temperatures on Elastohydrodynamic Lubrication Film Formation

Lubricants
The present study focuses on investigating the influence of oil and solid body temperatures on elastohydrodynamic lubrication (EHL) film formation. Experimental and numerical simulation methods are employed to examine three heating methods: oil and ball ...
Junbin Gao, Ping Yang, Xinming Li, Xuyang Jin, Ye Tian, Ziyang Cheng, Xu Yan   +6 more
doaj   +1 more source

A SPATIALLY RESOLVED VERTICAL TEMPERATURE GRADIENT IN THE HD 163296 DISK [PDF]

, 2013
We analyze sensitive, sub-arcsecond resolution ALMA science verification observations of CO emission lines in the protoplanetary disk hosted by the young, isolated Ae star HD 163296.
K. Rosenfeld, S. Andrews, A. Hughes, D. Wilner, C. Qi   +4 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of Temperature Gradient on the Microstructure of the Rapidly Solidified Nd-Fe-B Strips

, 2011
High-performance Nd-Fe-B magnets with nominal composition of Nd(13.25)Dy(0.2)Fe(78.87)Co(1)Cu(0.1)Al(0.5)B(6.08)%) have been produced by using strip casting technique.
Lee, Don, Zheng, Bo, Guo, Shuai, Guo, S, Yan, Guanghui, Chen, Renjie, Yan, Aru   +6 more
core   +1 more source

Simulation of Tandem Thin-Film Solar Cell on the Basis of CuInSe2

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2018
CuInSe2 thin-film solar cells are promising materials for photovoltaic devices. One of the main tasks of researchers is to find ways to increase the solar cells efficiency. In this paper we propose an original structure of a thin-film solar cell based on
A. K. Esman, V. K. Kuleshov, V. A. Potachits, G. L. Zykov   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source