Results 71 to 80 of about 5,330,759 (310)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Tree growth at the limits: the response of multiple conifers to opposing climatic constraints along an elevational gradient in the Alps

Frontiers in Forests and Global Change
IntroductionClimate change affects the vitality of mountain forests through increasing temperatures and decreasing water availability due to changing precipitation patterns, earlier snowmelt, and increasing evaporative demand.
Nikolaus Obojes, Serena Buscarini, Armin Konrad Meurer, Erich Tasser, Walter Oberhuber, Stefan Mayr, Ulrike Tappeiner, Ulrike Tappeiner   +7 more
doaj   +1 more source

Magnetoelectrets prepared by using temperature gradient method

, 2015
A novel Temperature Gradient method for preparation of magnetoelectret is proposed. Non uniform magnetic field and temperature gradient are expected to be the main cause for the formation of magnetoelectrets (MEs).
Pragya Ojha, M.M Malik, M.S Qureshi
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Effects of Oil and Solid Body Temperatures on Elastohydrodynamic Lubrication Film Formation

Lubricants
The present study focuses on investigating the influence of oil and solid body temperatures on elastohydrodynamic lubrication (EHL) film formation. Experimental and numerical simulation methods are employed to examine three heating methods: oil and ball ...
Junbin Gao, Ping Yang, Xinming Li, Xuyang Jin, Ye Tian, Ziyang Cheng, Xu Yan   +6 more
doaj   +1 more source

Simulation of Tandem Thin-Film Solar Cell on the Basis of CuInSe2

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2018
CuInSe2 thin-film solar cells are promising materials for photovoltaic devices. One of the main tasks of researchers is to find ways to increase the solar cells efficiency. In this paper we propose an original structure of a thin-film solar cell based on
A. K. Esman, V. K. Kuleshov, V. A. Potachits, G. L. Zykov   +3 more
doaj   +1 more source

Micro structure and Lagrangian statistcs of the scalar field with a mean gradient in isotropic turbulence [PDF]

, 2003
This paper presents an analysis and numerical study of the relations between the small-scale velocity and scalar fields in fully developed isotropic turbulence with random forcing of the large scales and with an imposed constant mean scalar gradient ...
Nieuwstadt, FTM, Hunt, JCR, Brethouwer, G   +2 more
core  

Characterization of Poly(2-vinylpyridine) by Temperature Gradient Interaction Chromatography

, 2016
Characterization of Poly(2-vinylpyridine) by Temperature Gradient Interaction ...
Soojin Park (516759), Taihyun Chang (1401064)   +1 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source