Results 81 to 90 of about 1,809,341 (305)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

New Geothermal Prospect in North-Eastern Morocco [PDF]

, 2010
Geothermal data has been indicating promising potentialities in the north-eastern Morocco. This paperpresents new temperature data, recently recorded in water borehole located in the Berkane and Oujda areas.
Barkaoui, Alae Eddine, Boughriba, Mimoun, Carneiro, Júlio, Correia, António, Lucazeau, Francis, Rimi, Abdelkrim, Verdoya, Massimo, Zarhloule, Yassine   +7 more
core  

Pomeranchuk effect and spin-gradient cooling of Bose-Bose mixtures in an optical lattice

, 2012
We theoretically investigate finite-temperature thermodynamics and demagnetization cooling of two-component Bose-Bose mixtures in a cubic optical lattice, by using bosonic dynamical mean field theory (BDMFT).
A. Auerbach, Liang He, M. Reza Bakhtiari, T. Ho, Walter Hofstetter, Yongqiang Li   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tree growth at the limits: the response of multiple conifers to opposing climatic constraints along an elevational gradient in the Alps

Frontiers in Forests and Global Change
IntroductionClimate change affects the vitality of mountain forests through increasing temperatures and decreasing water availability due to changing precipitation patterns, earlier snowmelt, and increasing evaporative demand.
Nikolaus Obojes, Serena Buscarini, Armin Konrad Meurer, Erich Tasser, Walter Oberhuber, Stefan Mayr, Ulrike Tappeiner, Ulrike Tappeiner   +7 more
doaj   +1 more source

Transient charge and energy flow in the wide-band limit [PDF]

, 2018
The wide-band limit is a commonly used approximation to analyze transport through nanoscale devices. In this work we investigate its applicability to the study of charge and heat transport through molecular break junctions exposed to voltage biases and ...
Covito, F., Eich, F. G., Rubio, A., Sentef, M. A., Tuovinen, R.   +4 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effects of Oil and Solid Body Temperatures on Elastohydrodynamic Lubrication Film Formation

Lubricants
The present study focuses on investigating the influence of oil and solid body temperatures on elastohydrodynamic lubrication (EHL) film formation. Experimental and numerical simulation methods are employed to examine three heating methods: oil and ball ...
Junbin Gao, Ping Yang, Xinming Li, Xuyang Jin, Ye Tian, Ziyang Cheng, Xu Yan   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source