Results 71 to 80 of about 1,793,986 (298)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Temperature gradient and Fourier's law in gradient-mass harmonic systems
, 2013 Heat flow and thermal profile in a 1D harmonic lattice with coordinate-dependent masses has been calculated in the thermodynamic limit. It is shown in the particular example of a 1D harmonic lattice with linearly increasing masses that in standard ...
Reich, K. V.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
New Geothermal Prospect in North-Eastern Morocco [PDF]
, 2010 Geothermal data has been indicating promising potentialities in the north-eastern Morocco. This paperpresents new temperature data, recently recorded in water borehole located in the Berkane and Oujda areas.
Barkaoui, Alae Eddine +7 more
core
Pomeranchuk effect and spin-gradient cooling of Bose-Bose mixtures in an optical lattice
, 2012 We theoretically investigate finite-temperature thermodynamics and demagnetization cooling of two-component Bose-Bose mixtures in a cubic optical lattice, by using bosonic dynamical mean field theory (BDMFT).
A. Auerbach +5 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Observation of a New Mechanism of Spontaneous Generation of Magnetic Flux in a Superconductor
, 2004 We report the discovery of a new mechanism of spontaneous generation of a magnetic flux in a superconductor cooled through $T_c$. The sign of the spontaneous flux changes randomly from one cooldown to the next, and follows a Gaussian distribution.
Ariel Maniv +11 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
TEMPERATURE GRADIENTS DURING HYPOTHERMIA [PDF]
Annals of the New York Academy of Sciences, 1959 V, HERCUS, D, COHEN, A C, BOWRING
openaire +4 more sources