Results 51 to 60 of about 22,877 (299)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Characterisation and Development of Nanostructured, Ultrahigh Strength, and Ductile Bainitic Steels

open access: yes, 2006
The purpose of the present work was to characterise and further develop a novel nanostructured type of bainitic steel. Three chemical compositions were considered with different concentrations of Al and Co.
Sherif MY, Sherif, Mohamed
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Effect of Heat Treatment on Mechanical Properties of 34CrNi3Mo Cast Steel

open access: yes工程科学与技术, 2012
: In order to research the effects of different heat treatment processes on mechanical properties of 34CrNi3Mo cast steel, the mechanical properties were compared in the condition of four kinds of heat treatment technologies which were “water ...
Wang De-fang, Yang Gang
doaj  

Optimization of Heat Treatment Parameters for the Tensile Properties of Medium Carbon Steel [PDF]

open access: yesEngineering and Technology Journal, 2018
The purpose of this study is designate quenching and tempering heat treatment by using Taguchi technique to determination optimal factors of heat treatment (tempering temperature, percentage of nanoparticles, type of base media, nanoparticles type and ...
Abbas Hussein, Laith Abbas, Wisam Hasan
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Optimasi Parameter Quenching dan Tempering pada HRP Steel Lokal sebagai Baja Armor Nasional

open access: yesRekayasa Mesin, 2018
Armor steel is a high strength and hardness steel that used to protect against damage by an object, individual or vehicle from the direct pressure of projectile.
Yurianto Yurianto   +2 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Variational Tempering

open access: yes, 2014
published version, 8 pages, 4 ...
Stephan Mandt   +4 more
openaire   +3 more sources

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