Results 71 to 80 of about 35,932 (299)
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
, 2015 Simulated tempering (ST) has attracted a great deal of attention in the last years, due to its capability to allow systems with complex dynamics to escape from regions separated by large entropic barriers. However its performance is strongly dependent on
daSilva, Cláudio J. +2 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Mechanical and Microstructural Behavior of Tempered CPM® 3V High-Density Sintered Tool Steel
Crystals, 2022 The tempering response of CPM® 3V tool steel was investigated via a hardening and tempering heat treatment, tensile testing, fractography, and microstructural evaluation.
Stephen A. C. Hanson, Sudhakar Vadiraja
doaj +1 more source
Simulating the Effects of Substrate Pre-Heating on the Final Structure of Steel Parts Built by Laser Powder Deposition [PDF]
, 2004 Tool steel parts built by laser powder deposition often present a heterogeneous distribution of properties caused by the complex structural transformations that occur during the deposition process.
Costa, L., Réti, T., Vilar, R.
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Thermostat-assisted continuously-tempered Hamiltonian Monte Carlo for Bayesian learning [PDF]
, 2018 We propose a new sampling method, the thermostat-assisted continuously-tempered Hamiltonian Monte Carlo, for Bayesian learning on large datasets and multimodal distributions.
Luo, Rui +4 more
core +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source
Simulation of tempering drying of porous media based on COMSOL multi-physics field
Shipin yu jixieObjectiveTo investigate the variation laws of temperature and humidity fields during the tempering process.MethodsUsing corn kernels and grain piles as porous media, perform multi-physics field coupling using the heat and moisture flow interface in the ...
LIU Dingtong +3 more
doaj +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez +5 more
wiley +1 more source