Results 91 to 100 of about 3,144,500 (368)
Advanced Materials Interfaces, 2016 Nanoparticles and their assemblies exhibit properties that can be used for a wide range of applications. However, creating multifunctional assemblies has remained challenging. Inspired by magnetotactic bacteria, genetically engineered single building blocks from magnetosome chains are used and complemented by additional components to form fluorescent ...
Jehle, F. +11 more
openaire +5 more sources
Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations [PDF]
Proceedings of the National Academy of Sciences, 2012 The accumulation of mutations causes cell lethality and can lead to carcinogenesis. An important class of mutations, which are associated with mutational hotspots in many organisms, are those that arise by nascent strand misalignment and template-switching at the site of short repetitive sequences in DNA.
Danna M. Zeiger +3 more
openaire +3 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Emergence of a code in the polymerization of amino acids along RNA templates. [PDF]
PLoS ONE, 2009 The origin of the genetic code in the context of an RNA world is a major problem in the field of biophysical chemistry. In this paper, we describe how the polymerization of amino acids along RNA templates can be affected by the properties of both ...
Jean Lehmann +2 more
doaj +1 more source
PLoS ONE, 2014 Recent research indicates that hundreds of thousands of G-rich sequences within the human genome have the potential to form secondary structures known as G-quadruplexes. Telomeric regions, consisting of long arrays of TTAGGG/AATCCC repeats, are among the
Deanna N. Edwards +3 more
semanticscholar +1 more source
SHIELD: Secure Haplotype Imputation Employing Local Differential Privacy [PDF]
arXiv, 2023 We introduce Secure Haplotype Imputation Employing Local Differential privacy (SHIELD), a program for accurately estimating the genotype of target samples at markers that are not directly assayed by array-based genotyping platforms while preserving the privacy of donors to public reference panels.
arxiv
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
ML Estimation of DNA Initial Copy Number in Polymerase Chain Reaction (PCR) Processes [PDF]
, 2007 Estimation of DNA copy number in a given biological sample is an extremely important problem in genomics. This problem is especially challenging when the number of the DNA strands is minuscule, which is often the case in applications such as pathogen and
Hassibi, A., Hassibi, B., Vikalo, H.
core +1 more source
Tripal v1.1: a standards-based toolkit for construction of online genetic and genomic databases
Database J. Biol. Databases Curation, 2013 Tripal is an open-source freely available toolkit for construction of online genomic and genetic databases. It aims to facilitate development of community-driven biological websites by integrating the GMOD Chado database schema with Drupal, a popular ...
L. Sanderson +6 more
semanticscholar +1 more source
When Darwin meets Lorenz: Evolving new chaotic attractors through genetic programming [PDF]
Chaos, Solitons & Fractals, Volume 76, Pages 141-155, 2015, 2014 In this paper, we propose a novel methodology for automatically finding new chaotic attractors through a computational intelligence technique known as multi-gene genetic programming (MGGP). We apply this technique to the case of the Lorenz attractor and evolve several new chaotic attractors based on the basic Lorenz template.
arxiv +1 more source