Results 81 to 90 of about 2,174,576 (296)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

OpenSourceEconomics/econ-project-templates: Actually update docs.

, 2021
Templates for reproducible economics ...
julienschat, PKEuS, Tobias Raabe, Hans-Martin, Radost Holler, jahaller, David LJ, Felix Albrecht, Philipp Müller   +8 more
core   +1 more source

Redesign of TALE proteins for DNA-templated assembly of protein fibers

Nature Communications
Many viral proteins self-assemble into capsid structures, often using their genetic material as a template for assembly. To date, de novo designed capsid-like proteins do not require genetic material as a template for assembly, which can be both an ...
Robbert J. de Haas, Mark D. Langowski, Andrew J. Borst, Visakh V. S. Pillai, Gwendolyn E. Hoffmann, Martin Bongers, Matthias Mulder, Suna Cheng, Catherine Treichel, Elizabeth M. Leaf, Mengyu Wu, Eric M. Lynch, Justin M. Kollman, Francesco S. Ruggeri, Carl Walkey, Renko de Vries, Neil P. King   +16 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery

EMBO Reports
To address a wide range of genetic diseases, genome editing tools that can achieve targeted delivery of large genes without causing double-strand breaks (DSBs) or requiring DNA templates are necessary.
Yuxiao Wang, Ruei-Zeng Lin, Meghan Harris, Bianca Lavayen, Neha Diwanji, Bruce McCreedy, Robert Hofmeister, Daniel Getts   +7 more
doaj   +1 more source

An FCM–GABPN Ensemble Approach for Material Feeding Prediction of Printed Circuit Board Template

Applied Sciences, 2019
Accurate prediction of material feeding before production for a printed circuit board (PCB) template can reduce the comprehensive cost caused by surplus and supplemental feeding.
Shengping Lv, Rongheng Xian, Denghui Li, Binbin Zheng, Hong Jin   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Webquest templates

, 2011
Customising word, excel and powerpoint templates so that webquest can be suited to any subject area.
LSN, Q Projects, Bishop Auckland College
core  

OpenSourceEconomics/econ-project-templates: Fix links and changelog

, 2022
Templates for reproducible economics ...
julienschat, Tim Mensinger, PKEuS, Tobias Raabe, Radost Holler, jahaller, David LJ, Felix Albrecht, Hans-Martin von Gaudecker, Philipp Müller   +9 more
core   +1 more source

Self-Organization of Template-Replicating Polymers and the Spontaneous Rise of Genetic Information [PDF]

Entropy, 2001
Living systems imply self-reproducing constructs capable of Darwinian evolution. How such dynamics can arise from undirected interactions between simple monomeric objects remains an open question. Here we circumvent difficulties related to the manipulation of chemical interactions, and present a system of ferromagnetic objects that self-organize into ...
openaire   +3 more sources