Results 81 to 90 of about 121,448 (310)
Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template
Molecular Systems Biology, 2011 Molecular Systems Biology, 7 (1)
Bleris, Leonidas +5 more
openaire +7 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
An analysis of procedural piano music composition with mood templates using genetic algorithms [PDF]
, 2018 Creating music in an automatic way has been studied since the beginning of artificial intelligence. One of the biggest obstacles of music generation is the vagueness and subjectivity of the mood or emotion transmitted by a music piece. In this work, we
Santos, Luísa Rocha de Azevedo
core
Harnessing the power of new genetic tools to illuminate Giardia biology and pathogenesis [PDF]
Giardia is a prevalent single-celled microaerophilic intestinal parasite causing diarrheal disease and significantly impacting global health. Double diploid (essentially tetraploid) Giardia trophozoites have presented a formidable challenge to the ...
McInally, Shane G +7 more
core +1 more source
Emerging trends in prime editing for precision genome editing
Experimental and Molecular MedicinePrime editing is an advanced genome editing technology that enables precise genetic modifications without inducing double-strand breaks or requiring donor DNA templates.
Jaesuk Lee, Jiyeon Kweon, Yongsub Kim
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Redesign of TALE proteins for DNA-templated assembly of protein fibers
Nature CommunicationsMany viral proteins self-assemble into capsid structures, often using their genetic material as a template for assembly. To date, de novo designed capsid-like proteins do not require genetic material as a template for assembly, which can be both an ...
Robbert J. de Haas +16 more
doaj +1 more source
Self-Organization of Template-Replicating Polymers and the Spontaneous Rise of Genetic Information [PDF]
Entropy, 2001 Living systems imply self-reproducing constructs capable of Darwinian evolution. How such dynamics can arise from undirected interactions between simple monomeric objects remains an open question. Here we circumvent difficulties related to the manipulation of chemical interactions, and present a system of ferromagnetic objects that self-organize into ...
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An FCM–GABPN Ensemble Approach for Material Feeding Prediction of Printed Circuit Board Template
Applied Sciences, 2019 Accurate prediction of material feeding before production for a printed circuit board (PCB) template can reduce the comprehensive cost caused by surplus and supplemental feeding.
Shengping Lv +4 more
doaj +1 more source