Results 61 to 70 of about 218,953 (302)

Drivers of within-host genetic diversity in acute infections of viruses.

open access: yesPLoS Pathogens, 2020
Genetic diversity is the fuel of evolution and facilitates adaptation to novel environments. However, our understanding of what drives differences in the genetic diversity during the early stages of viral infection is somewhat limited. Here, we use ultra-
Maoz Gelbart   +8 more
doaj   +1 more source

Review of Sex, Ecology, Spirituality by Ken Wilber 2nd ed 851p (2001) (review revised 2019) [PDF]

open access: yes, 2019
please see the full paper for the abstract as the moronic AI used by phil papers won't let me use it as it thinks it has a url in ...
Starks, Michael
core  

Genetic Programming for Multibiometrics

open access: yes, 2012
Biometric systems suffer from some drawbacks: a biometric system can provide in general good performances except with some individuals as its performance depends highly on the quality of the capture. One solution to solve some of these problems is to use
Giot, Romain, Rosenberger, Christophe
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Rapid Hypothesis Testing in Candida albicans Clinical Isolates Using a Cloning-Free, Modular, and Recyclable System for CRISPR-Cas9 Mediated Mutant and Revertant Construction

open access: yesMicrobiology Spectrum, 2022
As increasing evidence emerges that interstrain genetic diversity among Candida albicans clinical isolates underpins phenotypic variation compared to the reference isolate SC5314, new genetic tools are required to interrogate gene function across strain ...
Junyan Liu   +6 more
doaj   +1 more source

Review of Sex, Ecology, Spirituality by Ken Wilber 2nd ed. 851p (2001) [PDF]

open access: yes, 2016
It is both amazing and fitting that this huge, jargon-laden (this book really needs a glossary!), heavily academic work has become a best seller in the world of the educated.
Starks, Michael
core   +1 more source

ML Estimation of DNA Initial Copy Number in Polymerase Chain Reaction (PCR) Processes [PDF]

open access: yes, 2007
Estimation of DNA copy number in a given biological sample is an extremely important problem in genomics. This problem is especially challenging when the number of the DNA strands is minuscule, which is often the case in applications such as pathogen and
Hassibi, A., Hassibi, B., Vikalo, H.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Effective Use of Linear DNA in Cell-Free Expression Systems

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Cell-free expression systems (CFEs) are cutting-edge research tools used in the investigation of biological phenomena and the engineering of novel biotechnologies. While CFEs have many benefits over in vivo protein synthesis, one particularly significant
Megan A. McSweeney, Mark P. Styczynski
doaj   +1 more source

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