Results 51 to 60 of about 2,174,576 (296)
Human linear template with mammographic backgrounds estimated with a genetic algorithm
Journal of the Optical Society of America A, 2007 We estimated human observer linear templates underlying the detection of a realistic, spherical mass signal with mammographic backgrounds. Five trained naïve observers participated in two-alternative forced-choice (2-AFC) detection experiments with the signal superimposed on synthetic, clustered lumpy backgrounds (CLBs) in one condition and on ...
Castella C +5 more
openaire +3 more sources
F1000Research, 2023 A sound analysis of DNA sequencing data is important to extract meaningful information and infer quantities of interest. Sequencing and mapping errors coupled with low and variable coverage hamper the identification of genotypes and variants and the ...
Alex Mas-Sandoval +3 more
doaj +1 more source
Universal Multiplex PCR: a novel method of simultaneous amplification of multiple DNA fragments
Plant Methods, 2012 Background Multiplex PCR has been successfully applied in many areas since it was first reported in 1988; however, it suffers from poor universality.
Wen Daxing, Zhang Chunqing
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Drug Resistance in Cancers: A Free Pass for Bullying
Cells, 2022 The cancer burden continues to grow globally, and drug resistance remains a substantial challenge in cancer therapy. It is well established that cancerous cells with clonal dysplasia generate the same carcinogenic lesions.
Jing Li, Xiao Li, Qie Guo
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Genetic control of morphological transitions in a coacervating protein template
Soft MatterPoint mutations and thermal energy enable control over the assembly of a thermoresponsive silica-binding elastin-like polypeptide, while MD simulations and silicification reveal how the soft template transitions from micelle to proteinosome.
William C. Wixson +4 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Molecules, 2012 Toward the expansion of the genetic alphabet, an unnatural base pair between 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds) and pyrrole-2-carbaldehyde (Pa) functions as a third base pair in replication and transcription, and provides a useful tool for the site-
Rie Kawai +4 more
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Genetic diversity and differentiation of Pinus sylvestris L. from the IUFRO 1982 provenance trial revealed by AFLP analysis [PDF]
Archives of Biological Sciences, 2015 DNA markers have become effective tools in genetic diversity studies of forest trees. However, molecular marker analyses are associated with laborious and costly effort. One of the possibilities to overcome these constraints is to analyze bulked
Androsiuk Piotr +2 more
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