Results 91 to 100 of about 6,450,793 (333)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Multi-Feature Driver Variable Fusion Downscaling TROPOMI Solar-Induced Chlorophyll Fluorescence Approach

open access: yesAgronomy
Solar-induced chlorophyll fluorescence (SIF), as a direct indicator of vegetation photosynthesis, offers a more accurate measure of plant photosynthetic dynamics than traditional vegetation indices.
Jinrui Fan   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Temporal Reachability Graphs

open access: yes, 2012
While a natural fit for modeling and understanding mobile networks, time-varying graphs remain poorly understood. Indeed, many of the usual concepts of static graphs have no obvious counterpart in time-varying ones. In this paper, we introduce the notion
Conan, Vania   +3 more
core   +2 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

Do Trees Really Make a Difference to Our Perceptions of Streets? An Immersive Virtual Environment E-Participation Streetscape Study

open access: yesLand
Urban streets, constituting the majority of public space, are often designed to prioritise vehicular movement over the pedestrian experience, leading to environments that can feel unsafe and unwelcoming.
Marcus White   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Commentary on William Thomson's "Pitch Frames as Melodic Archetypes"

open access: yesEmpirical Musicology Review, 2006
While the concept of the perceptual “pitch frame” resembles leading theories of pitch structure in music in some respects, it contains some innovative elements that are discussed in this commentary. Additionally, the commentary focuses on the question of
David Temperley
doaj   +1 more source

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