Results 61 to 70 of about 2,572,386 (317)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Exploiting a graphplan framework in temporal planning

open access: yes, 2003
Graphplan (Blum and Furst 1995) has proved a popular and successful basis for a succession of extensions. An extension to handle temporal planning is a natural one to consider, because of the seductively time-like structure of the layers in the plan ...
Maria Fox, Long, D., Fox, M., Derek Long
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Riesgo de transmisión de la enfermedad de Chagas por intrusión de triatominos y mamíferos silvestres en Bucaramanga, Santander, Colombia

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2017
Introducción. La notificación de triatominos en las viviendas de algunos barrios de Bucaramanga motivó la realización de este estudio. Objetivo. Evaluar la intrusión de triatominos y mamíferos, así como algunos factores de riesgo para la enfermedad de ...
Marlene Reyes   +4 more
doaj   +1 more source

TEMPORAL LANDSLIDE SUSCEPTIBILITY ASSESSMENT USING LANDSLIDE DENSITY TECHNIQUE [PDF]

open access: yesGeological Behavior, 2017
In this study, a temporal landslide assessment was carried out in a landslide prone areaalong the RanauTambunan road in Sabah, Malaysia. The assessment was based on landslides interpreted from 1978 and 1994 aerial photographs and also from fieldworks ...
NNorbert Simon,   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

A cookbook for temporal conceptual data modelling with description logic

open access: yes, 2014
We design temporal description logics suitable for reasoning about temporal conceptual data models and investigate their computational complexity. Our formalisms are based on DL-Lite logics with three types of concept inclusions (ranging from atomic ...
Ryzhikov, Vladislav   +4 more
core   +1 more source

Agenda y Cuaderno de Nueva York: La paradoja entre la identidad í­ntima y la máscara múltiple

open access: yesOlivar: Revista de Literatura y Cultura Españolas, 2012
José Hierro es recordado en la historia de la literatura española por la poetización en sus obras de posguerra de un claro yo autoral, que cobra sentido casi siempre en cuanto englobado en el nosotros de una generación concreta y real: los textos ...
Elia Saneleuterio Temporal
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

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