Results 51 to 60 of about 469,391 (296)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
, 2005 The Resource Description Framework (RDF) is a metadata model and language recommended by the W3C. This paper presents a framework to incorporate temporal reasoning into RDF, yielding temporal RDF graphs. We present a semantics for temporal RDF graphs, a syntax to incorporate temporality into standard RDF graphs, an inference system for temporal RDF ...
Gutiérrez Gallardo, Claudio +2 more
openaire +3 more sources
IEEE Transactions on Neural Networks, 2003 Transient synchronization has been used as a mechanism of recognizing auditory patterns using integrate-and-fire neural networks. We first extend the mechanism to vision tasks and investigate the role of spike dependent learning. We show that such a temporal Hebbian learning rule significantly improves accuracy of detection. We demonstrate how multiple
Vasilaki, E., Feng, J., Buxton, Hilary
openaire +2 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Physica A: Statistical Mechanics and its Applications, 2009 We introduce the idea of temporal graphs, a representation that encodes temporal data into graphs while fully retaining the temporal information of the original data. This representation lets us explore the dynamic temporal properties of data by using existing graph algorithms (such as shortest-path), with no need for data-driven simulations.
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Anthropology & Aging, 2021 Sperm swimming in circles or a lone sperm cell with two heads: male reproductive aging is increasingly equated with poor sperm quality, the prevalence of offspring learning disabilities even schizophrenia. To discuss the construction of a male biological
Charlotte Kroløkke
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source