Results 101 to 110 of about 19,761,197 (221)

Tenascin-C targeting strategies in cancer

Matrix Biology
Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on
Dhaouadi, Sayda, Bouhaouala-Zahar, Balkiss, Orend, Gertraud   +2 more
openaire   +3 more sources

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Extracellular Matrix Remodeling in Actinic Cheilitis and Lip Squamous Cell Carcinoma: A Cross‐Sectional Study

Oral Diseases, EarlyView.
ABSTRACT Background Actinic cheilitis is a precursor to lip squamous cell carcinoma. How ultraviolet‐induced stromal degeneration relates to invasion‐related extracellular matrix markers remains unclear. This study investigated basophilic degeneration of collagen, solar elastosis, fibronectin, tenascin‐C, and podoplanin in both lesions.
Caroline Alfaia‐Silva, Polyane Caroline Arruda de Farias, Fernanda de Mello da Silva, Lidiane de Paula Ribeiro, Ericles de Paiva Vieira, Elena Riet Correa Rivero, Filipe Modolo   +6 more
wiley   +1 more source

Tenascin-C increases lung metastasis by impacting blood vessel invasions [PDF]

, 2019
Metastasis is a major cause of death in cancer patients. The extracellular matrix molecule tenascin-C is a known promoter of metastasis, however the underlying mechanisms are not well understood.
Oberndorfer, Felicitas, Averous, Gerlinde, van Der Heyden, Michael, Abou-Faycal, Chérine, Spenlé, Caroline, Oszwald, Andre, Sun, Zhen, Hussenet, Thomas, Kain, Renate, Bourdon, Catherine, Mathelin, Carole, Chenard, Marie-Pierre, Orend, Gertraud, Erne, William, Mangin, Pierre, Ahowesso, Constance, Midwood, Kim, Murdamoothoo, Devadarssen, Christofori, Gerhard, Loustau, Thomas, Yilmaz, Alev, Velázquez-Quesada, Inés, Klein, Annick, Deligne, Claire, Lefebvre, Olivier, Midwood K, Loustau T, Mangin P, Kain R, Spenlé C, Bourdon C, Ahowesso C, Murdamoothoo D, Abou-Faycal C, Sun Z, Velázquez-Quesada I, Chenard MP, Hussenet T, Erne W, Oberndorfer F, Mathelin C, Lefebvre O, Orend G, van der Heyden M, Oszwald A, Deligne C, Averous G, Klein A, Yilmaz A, Christofori G   +49 more
core   +1 more source

Expression of extracellular matrix proteins: tenascin-C, fibronectin and galectin-3 in prostatic adenocarcinoma

Journal of Health Sciences, 2015
Introduction: The interchanged stromal-epithelial relations and altered expression profiles of various extracellular matrix (ECM) proteins creates a suitable microenvironment for cancer development and growth.
Monika Ulamec, Davor Tomas, Tihana Dzombeta, Igor Tomaskovic, Borislav Spajić, Božo Krušlin   +5 more
doaj   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Auswirkungen von Tenascin–C, –R und –C/R–Defizienz auf den skelettalen Phänotyp von Mäusen mit hohem Lebensalter [PDF]

, 2005
Tenascin-Glykoproteine werden in der extrazellulären Matrix exprimiert; für Tenascin-C wurde eine Expression im Knochen nachgewiesen. Tenascin-Glykoproteine sind an Zellen-Matrix-Interaktionen beteiligt und sollen in den Binde- und Stützgeweben eine ...
Herberholz, Miriam
core   +1 more source

Thin films of Type 1 collagen for cell by cell analysis of morphology and tenascin-C promoter activity

BMC Biotechnology, 2006
Background The use of highly reproducible and spatiallyhomogeneous thin film matrices permits automated microscopy and quantitative determination of the response of hundreds of cells in a population.
Tona Alex, McDaniel Dennis, Elliott John T, Langenbach Kurt J, Plant Anne L   +4 more
doaj   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source