Biology, 2023 Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous cellular processes in embryonic development and can be increased in disease, or under conditions of trauma or cell stress in adults. However, the role of TNC in
Chantal Donovan +7 more
doaj +4 more sources
Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers [PDF]
Frontiers in Immunology, 2021 Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of ...
Ismaïl Hendaoui +19 more
doaj +5 more sources
Did Tenascin-C Co-Evolve With the General Immune System of Vertebrates? [PDF]
Frontiers in Immunology, 2021 Tenascin-C plays important roles in immunity. Toll-like receptor 4, integrin α9β1 and chemokines have already been identified as key players in executing the immune regulatory functions of tenascin-C.
Gertraud Orend +3 more
doaj +2 more sources
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression [PDF]
EMBO Molecular Medicine, 2021 Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for TIL. To
Devadarssen Murdamoothoo +18 more
doaj +3 more sources
Tenascin-C regulates CXCR4+ B cell migration and cortex formation in the developing bursa of Fabricius [PDF]
Frontiers in ImmunologyThe bursa of Fabricius (BF) is a unique primary lymphoid organ critical for B cell development in its specialized follicular microenvironment. Although the role of the follicular medulla required for B cell maturation is well characterized, the cellular ...
Ádám Soós +4 more
doaj +2 more sources
The Impact of 24-Month Etanercept Therapy on Changes in Adiponectin, Leptin and Tenascin C Levels in the Blood of Children with Juvenile Idiopathic Arthritis [PDF]
PharmaceuticalsBackground/Objectives: The most commonly diagnosed group of rheumatic diseases in children is juvenile idiopathic arthritis. It is characterized by a chronic inflammatory process that leads to the degradation of the bone and joint system and increased ...
Jan Siwiec +5 more
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An investigation of the relationship between Behçet’s disease and tenascin-C [PDF]
The Turkish Journal of GastroenterologyObjectives: The study aimed to investigate serum tenascin-C levels and its relationship with pathogenesis of Behçet’s disease (BD) with inflammatory processes.
Haydar Kaplan +3 more
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Frontiers in Immunology, 2023 Serum biomarkers are the gold standard in non-invasive disease diagnosis and have tremendous potential as prognostic and theranostic tools for patient stratification.
James Ozanne +8 more
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Tenascin-C, a Prognostic Determinant of Esophageal Squamous Cell Carcinoma. [PDF]
PLoS ONE, 2016 BACKGROUND:Tenascin-C, an adhesion modulatory extracellular matrix molecule, is highly expressed in numerous human malignancies; thus, it may contribute to carcinogenesis and tumor progression. We explored the clinicopathological significance of Tenascin-
Zhao-Ting Yang +7 more
doaj +1 more source
Early Days of Tenascin-R Research: Two Approaches Discovered and Shed Light on Tenascin-R
Frontiers in Immunology, 2021 Fritz G Rathjen
exaly +3 more sources