Results 11 to 20 of about 19,761,198 (221)
Journal of Cell Science, 2016 ABSTRACT Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin.
Midwood, Kim +3 more
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The Adhesion Modulating Properties of Tenascin-W [PDF]
International Journal of Biological Sciences, 2012 Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and tenascin-X also have anti-adhesive properties in vitro.
Florence Brellier, Enrico Martina, Matthias Chiquet, Jacqueline Ferralli, Michael van der Heyden, Gertraud Orend, Johannes C. Schittny, Ruth Chiquet-Ehrismann, Richard P. Tucker
doaj +3 more sources
The expression of tenascin‐C and tenascin‐W in human ossicles [PDF]
Journal of Anatomy, 2016 AbstractThe ossicles of the middle ear (the malleus, incus and stapes) transmit forces resulting from vibrations of the tympanic membrane to the cochlea where they are coded as sound. Hearing loss can result from diseases such as rheumatoid arthritis (RA) that affect the joints between the ossicles or degenerative processes like otosclerosis that lead ...
Tucker RP +4 more
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Tenascin-C Suppresses Rho Activation [PDF]
The Journal of Cell Biology, 2000 Cell binding to extracellular matrix (ECM) components changes cytoskeletal organization by the activation of Rho family GTPases. Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as fibronectin (FN).
Wenk, M, Midwood, K, Schwarzbauer, J
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Attenuated expression of tenascin-c in ovalbumin-challenged STAT4-/- mice [PDF]
Respiratory Research, 2011 Background Asthma leads to structural changes in the airways, including the modification of extracellular matrix proteins such as tenascin-C. The role of tenascin-C is unclear, but it might act as an early initiator of airway wall remodelling, as its ...
Virtanen Ismo +11 more
doaj +3 more sources
Expression and Immune Function of Tenascin-C
Critical Reviews™ in Immunology, 2011 Our immune system is designed to protect us from danger. Upon pathogen invasion and tissue injury, activation of both innate and adaptive immunity enables us to combat infection and to repair tissue damage. Tenascin-C is a large, extracellular matrix glycoprotein that has a very tightly controlled pattern of expression.
Udalova, I +3 more
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Serendipity; Close Encounter of Tenascin C [PDF]
Frontiers in Immunology, 2021 In 1924, Hans Spemann and Hilde Mangold established the concept of embryonic induction (1). They transplanted the dorsal grey crescent region of one newt gastrula to the ventral part of another newt gastrula and found that a piece of the transplant induced the host tissue into the formation of a secondary embryo.
Teruyo Sakakura
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Role of Serum Tenascin-C in Sepsis [PDF]
Zagazig University Medical Journal, 2021 Background: Sepsis can range in severity from infection to septic shock, and it can result in multiple organ dysfunction syndrome (MODS) and death. Tenascins are extracellular matrix glycoproteins that are expressed during multicellular organism growth ...
nora said +3 more
doaj +3 more sources
The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis
Medicine Science, 2021 Acute pancreatitis (AP) constitutes an activation of a variety of enzymes secreted by the pancreas and is a continuing inflammatory process where the pancreas damages itself.
Adil Ugur Cetin +4 more
doaj +1 more source
Tenascin-C and integrins in cancer [PDF]
Cell Adhesion & Migration, 2015 Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of ...
Yoshida, Toshimichi +2 more
openaire +2 more sources