Results 181 to 190 of about 19,761,197 (221)

Tenascin-C Induced Signaling in Cancer

Cancer Letters, 2006
Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying ...
Gertraud Orend, Ruth Chiquet-Ehrismann
exaly   +4 more sources

A virological view of tenascin-C in infection

American Journal of Physiology-Cell Physiology, 2023
Tenascin-C is a large extracellular matrix glycoprotein with complex, not yet fully unveiled roles. Its context- and structure-dependent modus operandi renders tenascin-C a puzzling protein. Since its discovery ∼40 years ago, research into tenascin-C biology continues to reveal novel functions, the most recent of all being its immunomodulatory ...
Lorena Zuliani-Alvarez, Anna M. Piccinini   +1 more
openaire   +2 more sources

Tenascin-C knockout mouse has no detectable tenascin-C protein

Journal of Neuroscience Research, 1997
A recent study by Mitrovic and Schachner (J Neurosci Res 42:710-717, 1995) reported the detection of a small amount of truncated tensacin-C (TN-C) in the nervous system of the TN-C knockout mice created by Saga et al. (Genes Dev 6:1821-1831, 1992).
D L, Settles, M, Kusakabe, D A, Steindler, H, Fillmore, H P, Erickson   +4 more
openaire   +2 more sources

Detection of tenascin‐C in the nervous system of the tenascin‐C mutant mouse

Journal of Neuroscience Research, 1995
AbstractWe have investigated the expression of tenascin‐C (TN‐C) in the somatosensory cortex of early postnatal mutant mice in which lacZ was reported to be expressed in place of tenascin (Saga et al.: Genes Dev 6:1821‐1831, 1992). At both the mRNA and protein levels, TN‐C was detected at levels lower in the mutant than in wild type animals by in situ ...
Mitrovic N, Schachner M
openaire   +3 more sources

Tenascin-C in astrocytic tumors

Surgical Neurology, 2002
Abstract The authors studied the expression of tenascin-C in 52 astrocytic tumor specimens and correlated it with proliferative indices. Tenascin-C immunoreactivity was found to be greater in tumor vessels and tumor networks of high-grade astrocytic tumors, and expression of TN-C in tumor vessels correlated with proliferative indices.
Giuseppe, Viale, Alessandra, Dorcaratto, Patrizia, Castellani, Laciano, Zardi   +3 more
openaire   +2 more sources

Immunolocalization of Tenascin-C in Vitiligo

Applied Immunohistochemistry & Molecular Morphology, 2012
The disappearance of melanocytes because of defective adhesion is one of the accepted theories to explain vitiligo. Tenascin-C is a large, extracellular matrix glycoprotein that is thought to inhibit adhesion of melanocytes to fibronectin. The current study aimed to evaluate the pattern of tenascin-C expression in vitiligenous skin compared with normal
Asmaa Gaber, Abdou, Alaa Hassan, Maraee, Mohamed Abd El-Monaem, Shoeib, Rania, Elbana   +3 more
openaire   +2 more sources

The tenascin-C knockout revisited

Journal of Cell Science, 1999
ABSTRACT In the past seven years, two groups have independently produced tenascin-C-knockout mice. These mice are born alive and, originally, were described as showing no abnormalities. More recent studies, many involving pathological intervention, have shown that tenascin-C-knockout mice have several defects.
E J, Mackie, R P, Tucker
openaire   +2 more sources

Role of tenascin-C in articular cartilage

Modern Rheumatology, 2017
Tenascin-C (TN-C) is a glycoprotein component of the extracellular matrix (ECM). TN-C consists of four distinct domains, including the tenascin assembly domain, epidermal growth factor-like repeats, fibronectin type III-like repeats, and the fibrinogen-like globe (FBG) domain. This review summarizes the role of TN-C in articular cartilage.
Masahiro, Hasegawa, Toshimichi, Yoshida, Akihiro, Sudo   +2 more
openaire   +2 more sources

The Role of Tenascin-C in Tissue Injury and Tumorigenesis [PDF]

Journal of Cell Communication and Signaling, 2009
The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer.
Kim S Midwood, Gertraud Orend
exaly   +2 more sources

Tenascin-C in the cochlea of the developing mouse

The Journal of Comparative Neurology, 1999
Tenascin-C is a glycoprotein of the extracellular matrix that acts in vitro as both a permissive and a nonpermissive substrate for neurite growth. We analyzed, by immunocytochemistry, the distribution of tenascin-C along neural growth pathways in the developing mouse cochlea.
D S, Whitlon, X, Zhang, M, Kusakabe
openaire   +2 more sources