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96 weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection

Journal of Hepatology, 2018
Tenofovir alafenamide (TAF) is a new prodrug of tenofovir developed to treat patients with chronic hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF) through more efficient delivery of tenofovir to hepatocytes. In 48-week results from two ongoing, double-blind, randomized phase III trials, TAF was non-inferior to
Kosh Agarwal, Young-Suk Lim, Scott Fung
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Tenofovir alafenamide fumarate for the treatment of HIV infection

Drugs of Today, 2016
Tenofovir alafenamide fumarate is a recently developed prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor with potent inhibitory activity against HIV. The utility of a previously developed tenofovir prodrug, tenofovir disoproxil fumarate, had been hampered by renal and bone mineral adverse events. Tenofovir alafenamide fumarate
R, Sampath, J, Zeuli, S, Rizza, Z, Temesgen   +3 more
openaire   +2 more sources

Weight changes in patients with sustained viral suppression switching tenofovir disoproxil fumarate to tenofovir alafenamide

Obesity, 2022
AbstractObjectiveSwitching from tenofovir disoproxil fumarate (TDF)‐ to tenofovir alafenamide (TAF)‐containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes and their association with TAF remain unclear.MethodsThis retrospective cohort evaluated ...
Jason J. Schafer, Matty Zimmerman, Ciara Walshe, Jesse Cerankowski, Ayako Shimada, Scott W. Keith   +5 more
openaire   +2 more sources

Tenofovir Alafenamide Fumarate Therapy for HIV Treatment: Cardiometabolic and Renal Safety

AIDS Research and Human Retroviruses, 2020
Antiretroviral treatment based on tenofovir alafenamide fumarate (TAF) is increasingly recommended, as it maintains the viral suppression and improves renal function and bone density in comparison with tenofovir disoproxil fumarate (TDF). We carried out a retrospective cohort study including experienced patients who switched treatment from TDF to TAF ...
Vasilis, Petrakis, Periklis, Panagopoulos, Stella, Papachristou, Nikolaos, Papanas, Irene, Terzi, Grigorios, Trypsianis, Dimitrios, Papazoglou   +6 more
openaire   +2 more sources

Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF)

Biochemical Pharmacology, 2016
Tenofovir alafenamide (TAF) can be considered a new prodrug of tenofovir (TFV), as successor of tenofovir disoproxil fumarate (TDF). It is in vivo as potent against human immunodeficiency virus (HIV) at a 30-fold lower dose (10mg) than TDF (300mg). TAF has been approved in November 2015 (in the US and EU), as a single-tablet regimen (STR) containing ...
openaire   +2 more sources

Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2

Diagnostic Microbiology and Infectious Disease, 2019
Tenofovir-associated renal toxicity is influenced by several factors, including plasma exposure and genetic variants in transporter-encoding genes. Tenofovir plasma exposure has been associated with a polymorphism in SLC28A2 gene (encoding the concentrative nucleoside transporter 2, CNT2): particularly, SLC28A2 124 CT/TT genotype patients show higher ...
Cusato J., Calcagno A., De Nicolo A., Mogyorosi K., D'Avolio A., Di Perri G., Bonora S.   +6 more
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[Tenofovir alafenamide fumarate - a new generation of tenofovir].

Klinicka mikrobiologie a infekcni lekarstvi, 2018
Antiretroviral therapy as a life-long treatment has to meet the criteria of maximum efficiency while maintaining the highest possible level of safety and tolerance. Tenofovir disoproxil fumarate (TDF) is an antiretroviral drug with an excellent effect of virological suppression.
Svatava, Snopková, Kateřina, Havlíčková, Petr, Husa   +2 more
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Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate

Journal of Gastroenterology and Hepatology, 2019
AbstractBackground and AimTenofovir alafenamide (TAF) is a new prodrug of tenofovir, enabling treatment of patients with hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF), via more efficient delivery of tenofovir to the hepatocytes.
Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Tsuguru Hayashi, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Mamoru Watanabe, Namiki Izumi   +18 more
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Tenofovir alafenamide compared to tenofovir disoproxil fumarate, induces dysglycemia, and dyslipidemia in Wistar rats

AIDS
Objectives: To determine the metabolic effects of tenofovir alafenamide (TAF) compared to tenofovir disoproxil fumarate (TDF) in vivo. Design and methods: Male Wistar rats (Rattus novergicus, 250–300 g body weight) were divided into three groups (n = 8) and orally treated daily with
Rajendraparsad, Hurchund, Sinegugu E, Sibiya, Bernard O, Owaga, Peter M O, Owira   +3 more
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Dolutegravir/emtricitabine/tenofovir-alafenamide/tenofovir-disoproxil-fumarate

Reactions Weekly, 2022
openaire   +1 more source