Results 61 to 70 of about 5,741,783 (179)

Reduced colony‐stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression

British Journal of Haematology, Volume 209, Issue 3, Page 939-952, September 2026.
Summary Targeting the colony‐stimulating factor 1 receptor (CSF1R) to remove tumour‐associated macrophages is being explored as cancer therapy. This strategy may be relevant for chronic lymphocytic leukaemia (CLL), which strongly depends on support from myeloid cells.
Natascha Rosen, Guillermo Rodriguez‐Real, Alexander F. vom Stein, Luca D. Schreurs, Trong‐Hieu Nguyen, Viktoria Kohlhas, Thanh‐Tung Truong, Maximilian Koch, Sebastian Reinartz, Sumiya Iqbal, Shaista Ilyas, Sanjay Mathur, Nina Reinart, Phuong‐Hien Nguyen, Michael Hallek   +14 more
wiley   +1 more source

Tenosynovial Giant-Cell Tumors of the Foot and Ankle

, 2017
Tenosynovial giant-cell tumor (TGCT) is the common term used to describe a group of soft-tissue tumors that share a common etiological link. Historically, the multiplicity of terms used to describe these tumors, in addition to contention regarding ...
Ethan J. Fraser, Martin Sullivan, Sullivan, Martin, Alexander Nesbitt, Fraser, Ethan J, Fiona Maclean, Nesbitt, Alexander, Maclean, Fiona   +7 more
core   +1 more source

Overview of Pharmacological Therapies for Diffuse Tenosynovial Giant Cell Tumor

Future Pharmacology, 2023
Tenosynovial giant cell tumor (TGCT) is a rare and locally aggressive benign tumor arising from the synovium of joints, bursae, and tendon sheaths. It is classified into localized (L-TGCT) and diffuse (D-TGCT) forms based on the extent of involvement ...
Antonia Stamatiou, Tu Nguyen-Ngoc, Laureline Wetterwald, Ana-Maria Dolcan, Giovanni Dei Tos, Stephane Cherix, Patrick Omoumi, Antonia Digklia   +7 more
doaj   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Chondroid tenosynovial giant cell tumor of temporomandibular joint

Annals of Maxillofacial Surgery, 2018
Tenosynovial giant cell tumor (TGCT), a benign proliferative lesion arising from the synovial membrane of the joints, is rarely seen in the temporomandibular joint. It frequently presents as a painful, preauricular swelling and affects the jaw functions. Two types of TGCT seen are diffuse TGCT (TGCT-D) and localized TGCT.
Shetty, Sujeeth Kumar, Hegde, Usha, Agarwal, Garima, Sreeshyla, H. S.   +3 more
openaire   +3 more sources

Patient-reported Symptoms of Tenosynovial Giant Cell Tumors [PDF]

Clinical Therapeutics, 2016
Tenosynovial giant cell tumor (TGCT), a rare locally aggressive neoplasm of the synovium of joints and tendon sheaths, is associated with joint destruction, inflammation, pain, and swelling, in part due to colony-stimulating factor 1 receptor-bearing macrophages recruited to the tumor by genetic elevation of colony-stimulating factor 1 activity.
Gelhorn, Heather L., Tong, Sandra, McQuarrie, Kelly, Vernon, Christina, Hanlon, Jennifer, Maclaine, Grant, Lenderking, William, Ye, Xin, Speck, Rebecca M., Lackman, Richard D., Bukata, Susan V., Healey, John H., Keedy, Vicki L., Anthony, Stephen P., Wagner, Andrew J., Von Hoff, Daniel D., Singh, Arun S., Becerra, Carlos R., Hsu, Henry H., Lin, Paul S., Tap, William D.   +20 more
openaire   +2 more sources

Histologically benign metastasizing tenosynovial giant cell tumor mimicking metastatic malignancy: A case report and review of literature

Radiology Case Reports, 2019
Diffuse-type tenosynovial giant cell tumor (D-TGCT), otherwise known as pigmented villonodular synovitis, is a locally aggressive tumor which can show multiple recurrences but is rarely associated with metastasis. A handful of studies have elucidated the
Eric L. Chen, AB, Carlos Manuel de Castro, IV, MD, Kevin D. Hendzel, BS, Suzanne Iwaz, MD, Michael A. Kim, MD, Ali Kord Valeshabad, MD, Mohammad Shokouh-amiri, MD, Karen L. Xie, DO   +7 more
doaj   +1 more source

Unusual chondroblastoma of the hand with large extraosseous soft tissue component

Radiology Case Reports, 2022
Chondroblastoma is a rare, benign primary cartilaginous bone tumor that typically arises in the epiphyses of the long bones. Radiologically, a well-defined lytic lesion with thin sclerotic margins is commonly found.
Justin Choi, B.A., Morgan A. Darrow, M.D., Lauren Zeitlinger, D.O., Steven W. Thorpe, M.D., Jasjeet Bindra, M.D.   +4 more
doaj   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Investigating vimseltinib in tenosynovial giant cell tumors

Expert Opinion on Pharmacotherapy
Tenosynovial giant cell tumors (TGCTs) are locally aggressive mesenchymal neoplasms that can cause chronic disability. Surgery is a mainstay of treatment but can carry a high risk of morbidity or can confer limited benefit. As such, effective alternative treatment options are needed, including systemic agents.
Victoria, Wytiaz, Rashmi, Chugh
openaire   +2 more sources