Results 71 to 80 of about 5,741,783 (179)

SHOULDER TUBERCULOSIS MIMICKING TENOSYNOVIAL GIANT CELL TUMOR IN CHILD: CASE REPORT

, 2020
The shoulder tuberculosis is rare in children, only few cases has been reported. Various clinical presentations make diagnosis more challenging. The synovial biopsy is the key stone to joint tuberculosis diagnosis.
El. Mouloua Ahmed , Aghoutane El. Mouhtadi , El. Khassoui Amine and Salama Tarik and El. Fezzazi Redouane
core   +1 more source

Integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant reveals universal TP53 abnormalities

Brain Pathology, Volume 36, Issue 4, July 2026.
This integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant expands the spectrum of associated genetic changes and underscores the presence of universal TP53 abnormalities at copy number, sequence, and protein expression level, with frequent yet largely unrecognized TP53 copy‐neutral loss of ...
Jorge A. Trejo‐Lopez, Cinthya Zepeda Mendoza, Thomas M. Kollmeyer, Kristen L. Drucker, Vanessa M. Pazdernik, Paul A. Decker, Corinne E. Praska, Jayson Hardcastle, Stephanie Smoley, Matthew Isaacson, Mallika Gandham, Surendra Dasari, Aditya Raghunathan, Caterina Giannini, Gang Zheng, Aaron Wagner, M. Beatriz Lopes, Kar‐Ming A. Fung, JoElle G. Peterson, Andreana L. Rivera, Christopher Rossi, Meggen A. Walsh, Zied Abdullaev, Kenneth Aldape, Martha Quezado, Drew Pratt, Patrick Joseph Cimino, Robert B. Jenkins, Cristiane M. Ida   +28 more
wiley   +1 more source

BILATERAL LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: CASE REPORT AND REVIEW [PDF]

Acta Ortopédica Brasileira, 2018
Objectives Several cases of bilateral diffuse pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor have been described in the literature. Nevertheless, some presentations are rare and differential diagnoses are necessary.
TIAGO LAZZARETTI FERNANDES, LIVIA DAU VIDEIRA, SANDRA UMEDA SASAKI, RENATO JOSÉ MENDONÇA NATALINO, ADRIANO MARQUES DE ALMEIDA, ANDRÉ PEDRINELLI, ARNALDO JOSÉ HERNANDEZ   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, Volume 600, Issue 11, Page 1638-1654, June 2026.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh, Richard Miallot, Chelsea De Bellis, Philippe Jolivet, Joanna Przybyl   +4 more
wiley   +1 more source

MRI features of an intra‐articular histiocytic sarcoma affecting the stifle joint in a dog

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 13‐year‐old, spayed, female German shorthaired pointer was presented for investigation of a right pelvic limb lameness and associated marked stifle swelling. Magnetic resonance imaging revealed a mildly heterogeneous, T2‐weighted hyperintense and T1‐weighted homogeneously hypointense, contrast‐enhancing fine nodular mass arising from the ...
Harriet Rhodes, Thorsten Rick, Joni Viitanen   +2 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Epidemiology of Knee Articular Cartilage Injuries in Patients Undergoing Arthroscopy: Insights From 25,293 Procedures at a High‐Volume Center

Orthopaedic Surgery, Volume 18, Issue 4, Page 670-684, April 2026.
This large, single‐center study provides a comprehensive cross‐sectional overview of cartilage injuries among 25,293 patients who underwent primary knee arthroscopy between 2017 and 2023. We found an overall prevalence of 66.2%, with 26.6% classified as severe (Outerbridge Grade III–IV).
Yanfang Jiang, Xiaoqing Hu, Hongshi Huang, Yong Ma, Xi Gong, Jianquan Wang, Yingfang Ao   +6 more
wiley   +1 more source

Chondroid Tenosynovial Giant Cell Tumor of the Temporomandibular Joint: A Rare Case Report [PDF]

, 2017
Tenosynovial giant cell tumor of diffuse type (TGCT-d) or pigmented villonodular synovitis (PVNS) is a locally aggressive lesion that mostly affects the joints of long bones.
Oslei Paes de Almeida, Barbara Maria Corrêa Geraldo, Geraldo, Barbara Maria Corrêa [UNESP], Ana Lia Anbinder, Carvalho, Yasmin Rodarte, Guimarães Filho, Rubens, Anbinder, Ana Lia [UNESP], Carvalho, Yasmin Rodarte [UNESP], Almeida, Oslei Paes de, Débora Lima Pereira, Anbinder, Ana Lia, Rubens Guimarães Filho, Yasmin Rodarte Carvalho, Geraldo, Barbara Maria Corrêa, de Almeida, Oslei Paes, Pereira, Débora Lima   +15 more
core   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source