Results 41 to 50 of about 5,762,549 (184)

A New Simple and Practical Clinical Classification for Tenosynovial Giant Cell Tumors of the Knee

Orthopaedic Surgery, 2022
Objective To propose a simple and practical clinical classification for tenosynovial giant cell tumor (TGCT) of the knee. Methods A retrospective study was conducted to verify the value and significance of this clinical classification.
Kai Zheng, Xiu‐chun Yu, Yong‐cheng Hu, Ming Xu, Jing‐yu Zhang   +4 more
doaj   +1 more source

Calcified Chondroid Mesenchymal Neoplasm of the Temporomandibular Joint: A Rare and Recently Described Benign Tumor. [PDF]

Case Rep Otolaryngol
The calcified chondroid mesenchymal neoplasm (CCMN) was first recognized as a distinct pathologic entity in 2021 at the University of Washington, and fewer than 100 cases of CCMN have been described in the literature. The CCMN tumor is characterized by the presence of chondroid matrix elements with an FN1–receptor TK gene fusion. CCMNs frequently arise
Yuan J, Lazaro T, Sekhar LN, Lee KC.
europepmc   +2 more sources

Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint destruction and bone erosion. Even if many treatments were developed with success in the last decades, some patients fail to respond, and disease chronicity is still a burden.
Marie Robert, Helena Farese, Pierre Miossec   +2 more
doaj   +1 more source

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. [PDF]

, 2013
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported.
Robert A Huddart, Sheila Seal, Eeles, Rosalind, Kote-Jarai, Zsofia, Elliot, Anna, Ruark, E, McDonald, Heather, Peto, Julian, D Timothy Bishop, Muir, K; id_orcid, Stratton, Michael R, Seal, Sheila, Turnbull, Clare, Kote-Jarai, Z, Muir, Kenneth (Kenneth R.), Kenneth Muir, Perdeaux, Elizabeth, Easton, Douglas F, McDonald, H, Zhang, Feng, Easton, Douglas F., Elizabeth Rapley, Muir, K, Seal, S, Janet Shipley, Perdeaux, E, Stratton, MR, Feng Zhang, KingWai Lau, Rahman, N, Huddart, RA, Bishop, DT, Rapley, Elizabeth, Rosalind Eeles, Stratton, Michael R., Huddart, Robert A, Heather McDonald, Huddart, R A, Nazneen Rahman, Muir, Kenneth, Elise Ruark, Shipley, Janet, McDonald, H. (Heather), UK Testicular Cancer Collaboration (UKTCC), Michael R Stratton, Anna Elliot, Nsengimana, J, Eeles, R, Jeremie Nsengimana, Elliot, A, Douglas F Easton, Shipley, J, UK Testicular Cancer Collaboration (UKTCC),, Turnbull, C, Elizabeth Perdeaux, Zsofia Kote-Jarai, Rapley, E. (Elizabeth), Bishop, D. Timothy (David Timothy), Clare Turnbull, Peto, J, Stratton, M R, Lau, Kingwai, Lau, K, Nsengimana, Jeremie, Ruark, Elise, Bishop, D Timothy, Easton, DF, Zhang, F, Rahman, Nazneen, Easton, D F, Rapley, E, Julian Peto, Bishop, D T, Huddart, Robert A.   +73 more
core   +1 more source

Diffuse-Type Tenosynovial Giant Cell Tumor Arising in the Temporomandibular Joint Extending to the External Auditory Canal: A Case Report and Literature Review

Ear, Nose & Throat Journal, 2023
A 74-year-old Japanese woman with a 1-year history of right preauricular pain and a 2-month history of bleeding from the right ear was admitted to our department. Tumor was observed in the anterior wall in the right external auditory canal. Bony swelling
Shiori Suzuki MD, Hiroshige Tsuda MD, PhD, Nobuyuki Bandoh MD, PhD, Takashi Goto MD, PhD, Akihiro Uemura MD, Takako Aoyama MD, Akimasa Nishio MD, PhD, Shujiroh Makino DDS, PhD, Tomomi Yamaguchi CT, Eriko Aimono MD, PhD, Hiroshi Nishihara MD, PhD, Yasuaki Harabuchi MD, PhD   +11 more
doaj   +1 more source

Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)

Bioorganic & Medicinal Chemistry Letters, 2022
Based on knowledge of kinase switch-control inhibition and using a combination of structure-based drug design and standard medicinal chemistry principles, we identified a novel series of dihydropyrimidone-based CSF1R kinase inhibitors displaying exquisite selectivity for CSF1R versus a large panel of kinases and non-kinase protein targets.
Timothy M, Caldwell, Yu Mi, Ahn, Stacie L, Bulfer, Cynthia B, Leary, Molly M, Hood, Wei-Ping, Lu, Lakshminarayana, Vogeti, Subha, Vogeti, Michael D, Kaufman, Scott C, Wise, Bertrand, Le Bourdonnec, Bryan D, Smith, Daniel L, Flynn   +12 more
openaire   +2 more sources

Tenosynovial giant cell tumor (TGCT): Mechanisms and advances in targeted treatments

Critical Reviews in Oncology/Hematology
Tenosynovial giant cell tumors (TGCT) are rare, locally aggressive, mesenchymal tumors occurring in the joints and tendon sheaths, which can cause pain, swelling, and have a substantial negative impact on patient quality of life. While surgery is the current standard of care for most cases of TGCT, there are several drawbacks including risk of ...
Hairong, Xu, Yuan, Li, Nong, Lin, Zhaoming, Ye, Xiaohui, Niu   +4 more
openaire   +2 more sources

Case Report: Giant cell lesions in the Maxillofacial region: diagnostic points and treatment strategies

Frontiers in Oncology
ObjectiveGiant cell-rich lesions in the maxillofacial region are relatively rare, and comprehensive clinical differential diagnostic protocols are currently lacking.
Xiaohan Gao, Xiaohan Gao, Shuangyi Wang, Shuangyi Wang, Xiaohong Zhan, Yanshan Liu, Yanshan Liu, Liqiang Chen, Liqiang Chen, Jian Sun, Jian Sun, Haoyue Xu, Haoyue Xu   +12 more
doaj   +1 more source

Additional file 1 of The diffuse-type tenosynovial giant cell tumor (dt-TGCT) patient journey: a prospective multicenter study

, 2021
Additional file 1. TOPP registry description, breakdown by country, participating centers, and patient-reported outcome measurements.
Bernthal, Nicholas M., Spierenburg, Geert, Healey, John H., Palmerini, Emanuela, Bauer, Sebastian, Gelderblom, Hans, Staals, Eric L., Lopez-Bastida, Julio, Fronk, Eva-Maria, Ye, Xin, Laeis, Petra, van de Sande, Michiel A. J.   +11 more
openaire   +1 more source

Tenosynovial Giant-Cell Tumors of the Foot and Ankle

, 2017
Tenosynovial giant-cell tumor (TGCT) is the common term used to describe a group of soft-tissue tumors that share a common etiological link. Historically, the multiplicity of terms used to describe these tumors, in addition to contention regarding ...
Ethan J. Fraser, Martin Sullivan, Sullivan, Martin, Alexander Nesbitt, Fraser, Ethan J, Fiona Maclean, Nesbitt, Alexander, Maclean, Fiona   +7 more
core   +1 more source