Results 71 to 80 of about 5,762,549 (184)

Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy

BMC Cancer, 2018
Background Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been implicated in the development of TGCT
Robert Nakayama, Jyothi Priya Jagannathan, Nikhil Ramaiya, Marco L. Ferrone, Chandrajit P. Raut, John E. Ready, Jason L. Hornick, Andrew J. Wagner   +7 more
doaj   +1 more source

Mouse Models of Osteosarcoma: Unraveling Disease Mechanisms and Accelerating Drug Discovery and Development

Cancer Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background Osteosarcoma is the most frequent primary bone malignancy, affecting mainly children, adolescents, and young adults. For the past 40 years, improvements in the survival of patients with osteosarcoma have been minimal, primarily as a consequence of the lack of systemic therapy options beyond traditional cytotoxic agents.
Staci L. Haney, Sarah A. Holstein
wiley   +1 more source

A Novel Case of Tenosynovial Giant Cell Tumor at 4 Years After Total Knee Arthroplasty for Medial Osteoarthritis With Synovial Osteochondromatosis

Case Reports in Orthopedics
We report an unusual case of a tenosynovial giant cell tumor (TGCT) in a patient who received a total knee arthroplasty (TKA) for medial knee osteoarthritis with synovial osteochondromatosis (SO).
Yu-uichi Mishima, Takao Kaneko, Kosuke Shiga, Ayakane Yamamoto, Shu Yoshizawa   +4 more
doaj   +1 more source

Clinical significance of immunocyte- and ferroptosis-related markers for the prognosis of patients with tenosynovial giant cell tumor: A cross-sectional study

Cancer Treatment and Research Communications
Background: Tenosynovial giant cell tumor (TGCT) comprises localized (L-TGCT) and diffuse (D-TGCT) subtypes, but how ferroptosis regulators, tumor-associated immune-cell markers and proliferation indices jointly relate to subtype and recurrence is poorly
Zhi-qiang Song, Yesitai Saierhali, Chen‑xi Li, Meng Wang, Bo Shao, Li Wang, Zhong‑cheng Gong   +6 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, Volume 19, Issue 10, Page 2833-2859, October 2025.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Pexidartinib for the treatment of adult patients with symptomatic tenosynovial giant cell tumor: safety and efficacy

, 2020
INTRODUCTION: Tenosynovial giant cell tumor (TGCT) is a benign clonal neoplastic proliferation arising from the synovium often causing pain, swelling, joint stiffness, and reduced quality of life.
Palmerini, Emanuela, Longhi, Alessandra, Donati, Davide Maria, Staals, Eric Lodewijk   +3 more
core   +2 more sources

Tenosynovial giant cell tumours [PDF]

, 2018
Tenosynoviale reusceltumoren (tenosynovial giant cell tumours, TGCT) zijn zeldzame goedaardige tumoren. Deze aandoening werd voorheen pigmented villonodular synovitis (PVNS) genoemd.
Mastboom, M.J.L.
core  

Chondroid Tenosynovial Giant Cell Tumor: A Clinicopathological and Immunohistochemical Analysis of 5 New Cases

, 2010
Tenosynovial giant cell tumor (TGCT) arises from the synovium of joints or tendon sheaths. Chondroid metaplasia in TGCT is rare with only 4 well-documented cases reported in the literature.
Benjamin L. Hoch, Roberto A. Garcia, Gert J. Smalberger   +2 more
core   +1 more source

Localized Giant Cell Tumor of Tendon Sheath of the Second Toe in a Young Diabetic Renal Transplant Patient

Foot & Ankle Surgery: Techniques, Reports & Cases
Localized tenosynovial giant cell tumor (lTGCT), formerly termed giant cell tumor of the tendon sheath (GCTTS), is a benign soft tissue neoplasm that commonly affects the hand and wrist, with rare involvement of the foot and toes.
Rafif Hamdan M. Almutairi, MBBS, Nadeem Afzal Sheikh, DPM   +1 more
doaj   +1 more source

Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Microglia interact with oxidative stress, reactive astrocytes, neuronal damage, neuroinflammation, synaptic dysfunction, mitochondrial dysfunction, epigenetic modifications, and blood–brain barrier disruption, playing a critical role in the pathophysiology of perioperative neurocognitive disorders (PND).
Xizhen Liu, Anke Zhang
wiley   +1 more source