Results 61 to 70 of about 4,796 (231)

Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock‐in mouse model

Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 494-508, May 2024.
Abstract Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with tyrosine hydroxylase deficiency (THD), a rare disorder with a wide phenotypic spectrum and variable response to treatment ...
Kunwar Jung‐KC, Alba Tristán‐Noguero, Altanchimeg Altankhuyag, David Piñol Belenguer, Karina S. Prestegård, Irene Fernandez‐Carasa, Arianna Colini Baldeschi, Maria Sigatulina Bondarenko, Angeles García‐Cazorla, Antonella Consiglio, Aurora Martinez   +10 more
wiley   +1 more source

Clinical and molecular profile of a Brazilian cohort of patients with classical BCR-ABL1-negative myeloproliferative neoplasms

Hematology, Transfusion and Cell Therapy, 2020
Background: The classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF).
Moysés Antonio Porto-Soares, Rafael Daltro de Oliveira, Gabriel Macedo Cortopassi, João Agostinho Machado-Neto, Leonardo Carvalho Palma, Lorena Lobo de Figueiredo-Pontes   +5 more
doaj   +1 more source

Modulation of the gut microbiome and Firmicutes phylum reduction by a nutraceutical blend in the obesity mouse model and overweight humans: A double‐blind clinical trial

Food Science &Nutrition, Volume 12, Issue 4, Page 2436-2454, April 2024.
The nutraceutical composition containing silymarin reduces the Firmicutes/Bacteroidetes ratio (F/B ratio). The nutraceutical composition of silymarin also lowers the De‐Ritis ratio, a biomarker for liver complications. The nutraceutical composition enriched with silymarin promotes an increase in Bacteroides caccae and Bacteroides uniformis, both ...
Victor Nehmi‐Filho, Jessica Alves de Freitas, Lucas Augusto Franco, Roberta Cristina Martins, José Antônio Orellana Turri, Aline Boveto Santamarina, Joyce Vanessa da Silva Fonseca, Ester Cerdeira Sabino, Bruna Carvalho Moraes, Erica Souza, Gilson Masahiro Murata, Silvia Figueiredo Costa, Paulo Sérgio Alcântara, José Pinhata Otoch, Ana Flávia Marçal Pessoa   +14 more
wiley   +1 more source

Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VI: Accreditation process. [PDF]

Hematol Transfus Cell Ther, 2021
De Santis GC, Ubiali EMA, Zanelli APRD, Mendrone Junior A, Feitoza A, Kutner JM, Orellana MD, Rizzo SRCP, Covas DT, Langhi Junior DM.   +9 more
europepmc   +1 more source

New methodologies for old problems: tridimensional gastrointestinal organoids and guts-on-a-chip

Journal of Coloproctology, 2018
Objectives: The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research. Methods: A literature review was performed
Marna Eliana Sakalem, João Tadeu Ribeiro-Paes   +1 more
doaj   +1 more source

Chimeric antigen receptor T‐cell therapy outcomes in T cell/histiocyte‐rich large B‐cell lymphoma and subsequent treatment strategies after disease progression: A GELTAMO/GETH study

HemaSphere, Volume 9, Issue 2, February 2025.
Mariana Bastos‐Oreiro, Gloria Iacoboni, Víctor N. Garcés, Ana C. Caballero, Nuria Martínez, Javier Delgado, Aitana Balaguer, Mi Kwon, Sonia Gonzalez de Villambrosia, Rafael Hernani, Ana Jimenez‐Ubieto, Rebeca Bailen, Izaskun Zaberio, Alejandro Martín García‐Sancho, Pere Barba   +14 more
wiley   +1 more source

Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. V: Manufacture and quality control. [PDF]

Hematol Transfus Cell Ther, 2021
De Santis GC, Langhi Junior DM, Feitoza A, Mendrone Junior A, Kutner JM, Covas DT, Couto SCF, Guerino-Cunha RL, Orellana MD, Rizzo SRCP.   +9 more
europepmc   +1 more source

Perfusão miocárdica quantitativa por ressonância magnética cardiovascular na doença arterial coronariana difusa tratada com revascularização cirúrgica associada à terapia celular: um subestudo do MiHeart/IHD [PDF]

, 2020
Antonildes Nascimento Assunção Júnior
openalex   +1 more source

Perspectivas de terapia celular em neurologia

Revista de Medicina, 2015
<p>Neste artigo de revisão, buscamos ressaltar alguns dos avanços mais recentes na pesquisa sobre células-tronco em neurologia. Além disso, buscamos demonstrar a direta associação entre seu funcionamento e mecanismos de replicação, diferenciação e maturação, além da terapêutica celular de algumas doenças neurológicas.
Fernando Onuchic, Chary Marquez Batista, Guilherme Lepski   +2 more
openaire   +2 more sources

Terapia celular na Esclerose Lateral Amiotrófica

Revista Neurociências, 2001
Introdução. A Esclerose Lateral Amiotrófica é a doença de neurônio motor mais comum na idade adulta, com prognóstico sombrio e limitadas opções de tratamento o que leva a exploração de terapias alternativas. Método. Este trabalho, através de uma revisão da literatura, buscou descrever os avanços da utilização de células-tronco no tratamento da ...
Ronald Pallotta, Antônio Andrade, Clara Magalhaes Paiva   +2 more
openaire   +1 more source