Results 1 to 10 of about 14,020 (183)

Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington’s Disease [PDF]

Life
Huntington’s disease is a genetic disorder characterized by progressive neuronal cell damage in some areas of the brain; symptoms are commonly associated with chorea, rigidity and dystonia.
Sergio Adrian Ocampo-Ortega, Vivany Maydel Sierra-Sanchez, Citlali Margarita Blancas-Napoles, Asdrúbal González-Carteño, Elvia Mera-Jiménez, Martha Edith Macías-Pérez, Adriana Hernandez-Guerra, Rodrigo Romero-Nava, Fengyang Huang, Enrique Hong, Santiago Villafaña   +10 more
doaj   +2 more sources

AAV-HDV: An Attractive Platform for the In Vivo Study of HDV Biology and the Mechanism of Disease Pathogenesis

Viruses, 2021
Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, but little is known about the molecular mechanisms involved. We have recently developed an HDV mouse model based on the delivery of HDV replication-competent genomes ...
Sheila Maestro, Nahia Gómez-Echarte, Gracián Camps, Carla Usai, Lester Suárez, África Vales, Cristina Olagüe, Rafael Aldabe, Gloria González-Aseguinolaza   +8 more
doaj   +1 more source

EFFECT OF SUPPLEMENTATION WITH TYPICAL MEXICAN FOODS (OPTUNA FICUS INDICA, THEOBROMA CACAO AND EDIBLE CRICKETS) IN HIGH-FAT/HIGH-SUGAR DIET-FED MICE

Annals of Hepatology, 2022
Introduction and objectives: The obesogenic environment, including high fat/ high sugar diet, are risk factors for developing multiple diseases associated with obesity, such as metabolic-associated fatty liver disease (MAFLD) and metabolic syndrome ...
R. Rosas Campos, A. Meza Ríos, S. Rodríguez Sanabria, R. de la Rosa Bibiano, A. Sandoval Rodríguez, J. Armendáriz Borunda   +5 more
doaj   +1 more source

Moringa oleifera decreases biomarkers of oxidative stress in a murine NASH model

Annals of Hepatology, 2022
Introduction and Objectives: This study aimed to evaluate the effect of Moringa oleifera aqueous extract on biomarkers of oxidative stress in a murine model of NASH. Material and Methods: The characterization of the extract was performed by DPPH and ABTS
A Monraz-Méndez, A Monraz-Méndez, R Escutia-Gutiérrez, JS Rodríguez-Sanabria, L Sánchez-Orozco, J Armendáriz-Borunda, A Sandoval-Rodríguez   +6 more
doaj   +1 more source

terapia génica en México y España, una aproximación bioética desde la investigación científica

Revista de Bioética y Derecho, 2021
La terapia génica es una línea de investigación que, por medio de la transferencia genética, busca nuevos tratamientos a enfermedades que son difíciles de tratar mediante métodos tradicionales.
Alvaro Olivo Yepez, Pascual Linares Márquez, Ivan Delgado Encisio, Zoylo Morales Romero   +3 more
doaj   +1 more source

Targeted Expression to Liver of an antimiR-33 Sponge as a Gene Therapy Strategy against Hypercholesterolemia: In Vitro Study

Current Issues in Molecular Biology, 2023
Atherosclerosis is the leading cause of cardiovascular diseases in Mexico and worldwide. The membrane transporters ABCA1 and ABCG1 are involved in the reverse transport of cholesterol and stimulate the HDL synthesis in hepatocytes, therefore the ...
Mariela Montaño-Samaniego, Jorge Sánchez-Cedillo, Amellalli Lucas-González, Diana M. Bravo-Estupiñan, Ernesto Alarcón-Hernández, Sandra Rivera-Gutiérrez, José Abraham Balderas-López, Miguel Ibáñez-Hernández   +7 more
doaj   +1 more source

Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters

Frontiers in Oncology, 2020
Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases, due to the lack of early diagnosis, and high relapse rate after conventional therapies.
Mariela Montaño-Samaniego, Diana M. Bravo-Estupiñan, Oscar Méndez-Guerrero, Ernesto Alarcón-Hernández, Miguel Ibáñez-Hernández   +4 more
doaj   +1 more source

Oxidative and Fibrinolytic Mechanisms: Two Important Processes to Consider in Platelet Storage

Turkish Journal of Hematology, 2023
Objective: Platelet-rich plasma (PRP) is used in multiple coagulation disorders. Its therapeutic effectiveness relies on technical procedures related to PRP procurement and preservation because free radicals induce platelet activation and aging.
Jesus Javier Garcia-Bañuelos, Marina Galicia-Moreno, Hugo Christian Monroy-Ramírez, Jose Navarro-Partıda, Blanca Estela Bastidas Ramirez, Arturo Santos, Juan Armendariz-Borunda   +6 more
doaj   +1 more source

Fluorescence-Linked Aptamer Assay for SARS-CoV-2 Spike-Protein: A Step-by-Step Performance Analysis in Clinical Samples

Diagnostics, 2022
The COVID-19 pandemic has been a main concern over the last two years and has become one of the most important crises in the history of human health. Today, there is still a need for affordable and reliable diagnostic tests for massive disease monitoring.
Pablo Alberto Franco-Urquijo, Mónica Sierra-Martínez, Mariana Jarquín-Martínez, Mateo Alejandro Martínez-Roque, Victor Miguel García-Velásquez, Gustavo Acosta-Altamirano, Nancy Jannet Ruiz-Pérez, Julia Dolores Toscano-Garibay, Luis Marat Alvarez-Salas   +8 more
doaj   +1 more source

Exploring the metabolic and molecular benefits of methyl donor supplementation in a model of metabolic and fatty liver disease

Annals of Hepatology
Introduction and Objectives: Metabolic fatty liver disease (MAFLD) is currently the most common cause of chronic liver damage worldwide. Differential methylation in genes and histones has been correlated with metabolic alterations present in the disease.
Angel Vazquez-Esqueda, Rebeca Rosas-Campos, Rebeca Escutia-Gutiérrez, Ricardo de la Rosa-Bibiano, Samael Rodríguez-Sanabria, Marina Galicia-Moreno, Juan Armendáriz-Borunda, Ana Sandoval-Rodríguez   +7 more
doaj   +1 more source