Results 11 to 20 of about 2,202 (173)

Terapia Génica [PDF]

Medicina, 2001
<p><strong>Definición</strong><br />La terapia génica es el proceso por el cual se inserta material genético en una célula, con el fin de hacer que ésta produzca una proteína normal.
Ignacio Zarante
doaj   +1 more source

Gremlin-1 Drives Tumour Vascularization by Promoting Endothelial Differentiation and Angiogenesis. [PDF]

J Cell Mol Med
ABSTRACT Gremlin‐1 is a secreted antagonist of bone morphogenetic protein (BMP) signalling, highly expressed in various malignant tumours and is associated with poor prognosis. In addition to its established pro‐angiogenic activity, its potential role in endothelial differentiation in tumour contexts remains incompletely defined.
Mitola S, Ronca R, Presta M, Corsini M.
europepmc   +2 more sources

Quantifying and Leveraging Interfacial Amine Reactivity in Block Copolymer Nanoparticles for Advanced Material Design. [PDF]

Small Sci
Amine‐functionalized block copolymer nanoparticles were synthesized via RAFT‐PISA with rigorous quantification of interfacial amine accessibility. The surface‐reactive amines served as modular handles for postassembly conjugation with fluorescent dyes and thermoresponsive polymers, conferring optical trackability and stimuli‐responsive behaviors ...
Steffè A, Rosetti B, Valente S, Sbacchi M, Battistin F, Tecilla P, Gobbo P.   +6 more
europepmc   +2 more sources

Estrogen-ER-α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 14, Issue 1, January 2024.
Cherubini A, Casirati E, Pelusi S, Valenti L.   +3 more
europepmc   +2 more sources

Terapia génica en el manejo de las distrofias retinianas [PDF]

, 2018
La terapia génica se define como los procedimientos de transferencia de material genético a órganos específicos, con el propósito de producir efectos terapéuticos para así corregir defectos o enfermedades genéticas, ya sea de forma directa (in vivo) o ...
Hernández, Luz Ángela, Tachack Abril, Ginna Tatiana, Henao Calderón, José Luis   +2 more
core   +5 more sources

Novel Para-Phenylenediamine-Based Derivatives as Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization. [PDF]

ChemMedChem
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Smaldone G, Miranda MR, Di Matteo F, Napolitano V, Aliberti M, Musella S, Di Sarno V, Lauro G, Bifulco G, Pepe G, Aquino G, Tecce MF, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Bertamino A, Vestuto V, Ciaglia T.   +17 more
europepmc   +2 more sources

Luspatercept for Transfusion-Dependent Beta-Thalassemia: Real-World Experience in a Large Cohort of Patients From Italy. [PDF]

Am J Hematol
American Journal of Hematology, Volume 100, Issue 9, Page 1651-1655, September 2025.
Origa R, Gianesin B, Zappu A, Denotti AR, Di Giorgio MA, Sciortino R, Motta I, Panzieri DL, Rosso R, Bulla A, Culcasi M, Pasanisi AM, De Franceschi L, Di Maggio R, Pinto VM, Sanna PMG, Ricchi P, Ruffo GB, Schieppati F, Roberti D, Ferrero GB, De Michele E, Arcioni F, Fotzi I, Marktel S, Poloni A, Soverini G, Testa ER, Cabiddu G, Fortugno C, Gigante A, Polese F, Rapezzi D, Sau A, Forni GL, Cappellini MD, Longo F.   +36 more
europepmc   +2 more sources

Terapia génica. Perspectivas y consideraciones éticas en relación con su aplicación [PDF]

Revista Habanera de Ciencias Médicas, 2008
La Terapia Génica es una metodología que aborda la inserción de material genético en un individuo para tratar una enfermedad ya sea de forma directa (in vivo) o indirectamente, a través del uso de células como vehículo de liberación (ex vivo).
Salomé Rocío García Miniet, María Elena González Fraguela   +1 more
doaj   +2 more sources

Traffic light at DSB-transit regulation between gene transcription and DNA repair. [PDF]

FEBS Lett
Upon the generation of a break, DNA damage response activation represses transcription of genes in cis via an ATM‐ and PRC1‐dependent chromatin modification and compaction. Concomitantly, RNAPII accumulates in proximity to DNA ends and locally synthesizes chromatin‐bound ncRNAs.
Modafferi S, Esposito F, Tavella S, Gioia U, Francia S.   +4 more
europepmc   +2 more sources

Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer

Cancer Medicine, Volume 12, Issue 24, Page 22130-22155, December 2023., 2023
Abstract The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present. It is one of the means through which cancer cells actively cope with the potential damaging effects of aneuploidy, a hallmark of most
Diana M. Bravo‐Estupiñan, Karol Aguilar‐Guerrero, Steve Quirós, Man‐Sai Acón, Christian Marín‐Müller, Miguel Ibáñez‐Hernández, Rodrigo A. Mora‐Rodríguez   +6 more
wiley   +1 more source