Results 11 to 20 of about 236,465 (163)

Terapia Génica

Medicina, 2001
<p><strong>Definición</strong><br />La terapia génica es el proceso por el cual se inserta material genético en una célula, con el fin de hacer que ésta produzca una proteína normal.
Ignacio Zarante
doaj   +1 more source

Terapia génica: una opción de tratamiento y una controversia ética [PDF]

Salud Uninorte, 2013
La terapia génica es un procedimiento innovador que esboza en su aplicación conflictos po- tenciales de orden médico, ético, económico y social. Puede ser definida como la transferen- cia de genes a células humanas específicas con el objetivo de producir
Camilo Andrés Agudelo Vélez, Lina María Martínez Sánchez   +1 more
doaj   +2 more sources

La Terapia Génica y la Dermatología [PDF]

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2001
Terapia Génica y la ...
Asociación Colombiana de Dermatología
doaj   +1 more source

Gremlin-1 Drives Tumour Vascularization by Promoting Endothelial Differentiation and Angiogenesis. [PDF]

J Cell Mol Med
ABSTRACT Gremlin‐1 is a secreted antagonist of bone morphogenetic protein (BMP) signalling, highly expressed in various malignant tumours and is associated with poor prognosis. In addition to its established pro‐angiogenic activity, its potential role in endothelial differentiation in tumour contexts remains incompletely defined.
Mitola S, Ronca R, Presta M, Corsini M.
europepmc   +2 more sources

Estrogen-ER-α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 14, Issue 1, January 2024.
Cherubini A, Casirati E, Pelusi S, Valenti L.   +3 more
europepmc   +2 more sources

Quantifying and Leveraging Interfacial Amine Reactivity in Block Copolymer Nanoparticles for Advanced Material Design. [PDF]

Small Sci
Amine‐functionalized block copolymer nanoparticles were synthesized via RAFT‐PISA with rigorous quantification of interfacial amine accessibility. The surface‐reactive amines served as modular handles for postassembly conjugation with fluorescent dyes and thermoresponsive polymers, conferring optical trackability and stimuli‐responsive behaviors ...
Steffè A, Rosetti B, Valente S, Sbacchi M, Battistin F, Tecilla P, Gobbo P.   +6 more
europepmc   +2 more sources

Novel Para-Phenylenediamine-Based Derivatives as Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization. [PDF]

ChemMedChem
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Smaldone G, Miranda MR, Di Matteo F, Napolitano V, Aliberti M, Musella S, Di Sarno V, Lauro G, Bifulco G, Pepe G, Aquino G, Tecce MF, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Bertamino A, Vestuto V, Ciaglia T.   +17 more
europepmc   +2 more sources

Luspatercept for Transfusion-Dependent Beta-Thalassemia: Real-World Experience in a Large Cohort of Patients From Italy. [PDF]

Am J Hematol
American Journal of Hematology, Volume 100, Issue 9, Page 1651-1655, September 2025.
Origa R, Gianesin B, Zappu A, Denotti AR, Di Giorgio MA, Sciortino R, Motta I, Panzieri DL, Rosso R, Bulla A, Culcasi M, Pasanisi AM, De Franceschi L, Di Maggio R, Pinto VM, Sanna PMG, Ricchi P, Ruffo GB, Schieppati F, Roberti D, Ferrero GB, De Michele E, Arcioni F, Fotzi I, Marktel S, Poloni A, Soverini G, Testa ER, Cabiddu G, Fortugno C, Gigante A, Polese F, Rapezzi D, Sau A, Forni GL, Cappellini MD, Longo F.   +36 more
europepmc   +2 more sources

Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer

Cancer Medicine, Volume 12, Issue 24, Page 22130-22155, December 2023., 2023
Abstract The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present. It is one of the means through which cancer cells actively cope with the potential damaging effects of aneuploidy, a hallmark of most
Diana M. Bravo‐Estupiñan, Karol Aguilar‐Guerrero, Steve Quirós, Man‐Sai Acón, Christian Marín‐Müller, Miguel Ibáñez‐Hernández, Rodrigo A. Mora‐Rodríguez   +6 more
wiley   +1 more source

Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease

Glia, Volume 71, Issue 3, Page 571-587, March 2023., 2023
Main Points Myeloid cells adopt an anti‐inflammatory phenotype in the midbrain and a pro‐inflammatory profile in the striatum of α‐synuclein‐overexpressing mice. Astrocytes in the midbrain of α‐synuclein mice are involved in the pro‐inflammatory reaction.
Leyre Basurco, Miguel Angel Abellanas, Leyre Ayerra, Enrique Conde, Rodrigo Vinueza‐Gavilanes, Esther Luquin, Africa Vales, Amaya Vilas, Patxi San Martin‐Uriz, Ibon Tamayo, Marta M. Alonso, Mikel Hernaez, Gloria Gonzalez‐Aseguinolaza, Pedro Clavero, Elisa Mengual, Montserrat Arrasate, Sandra Hervás‐Stubbs, Maria S. Aymerich   +17 more
wiley   +1 more source