Results 11 to 20 of about 14,058 (179)

Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer

open access: yesCancer Medicine, Volume 12, Issue 24, Page 22130-22155, December 2023., 2023
Abstract The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present. It is one of the means through which cancer cells actively cope with the potential damaging effects of aneuploidy, a hallmark of most
Diana M. Bravo‐Estupiñan   +6 more
wiley   +1 more source

Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease

open access: yesGlia, Volume 71, Issue 3, Page 571-587, March 2023., 2023
Main Points Myeloid cells adopt an anti‐inflammatory phenotype in the midbrain and a pro‐inflammatory profile in the striatum of α‐synuclein‐overexpressing mice. Astrocytes in the midbrain of α‐synuclein mice are involved in the pro‐inflammatory reaction.
Leyre Basurco   +17 more
wiley   +1 more source

Macrophage migration inhibitory factor gene polymorphisms (SNP ‐173 G>C and STR‐794 CATT5‐8) confer risk of plaque psoriasis: A case–control study

open access: yesJournal of Clinical Laboratory Analysis, Volume 35, Issue 11, November 2021., 2021
Summary of key results from this study. (1) “Linkage disequilibrium was identified between ‐173 G>C and STR‐794 CATT5‐8 polymorphisms (D′ value = 0.62, r2 = 0.17, p < 0.001, Figure 1). (2) “the ‐173 CC genotype was associated with high MIF serum levels ".
Jorge Hernández‐Bello   +7 more
wiley   +1 more source

Targeted Expression to Liver of an antimiR-33 Sponge as a Gene Therapy Strategy against Hypercholesterolemia: In Vitro Study

open access: yesCurrent Issues in Molecular Biology, 2023
Atherosclerosis is the leading cause of cardiovascular diseases in Mexico and worldwide. The membrane transporters ABCA1 and ABCG1 are involved in the reverse transport of cholesterol and stimulate the HDL synthesis in hepatocytes, therefore the ...
Mariela Montaño-Samaniego   +7 more
doaj   +1 more source

Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters

open access: yesFrontiers in Oncology, 2020
Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases, due to the lack of early diagnosis, and high relapse rate after conventional therapies.
Mariela Montaño-Samaniego   +4 more
doaj   +1 more source

Oxidative and Fibrinolytic Mechanisms: Two Important Processes to Consider in Platelet Storage

open access: yesTurkish Journal of Hematology, 2023
Objective: Platelet-rich plasma (PRP) is used in multiple coagulation disorders. Its therapeutic effectiveness relies on technical procedures related to PRP procurement and preservation because free radicals induce platelet activation and aging.
Jesus Javier Garcia-Bañuelos   +6 more
doaj   +1 more source

Differential Expression and PAH Degradation: What Burkholderia vietnamiensis G4 Can Tell Us?

open access: yesInternational Journal of Microbiology, Volume 2020, Issue 1, 2020., 2020
Petroleum is the major energy matrix in the world whose refining generates chemical byproducts that may damage the environment. Among such waste, polycyclic aromatic hydrocarbons (PAH) are considered persistent pollutants. Sixteen of these are considered priority for remediation, and among them is benzo(a)pyrene.
Guilherme Pinto Cauduro   +5 more
wiley   +1 more source

Fluorescence-Linked Aptamer Assay for SARS-CoV-2 Spike-Protein: A Step-by-Step Performance Analysis in Clinical Samples

open access: yesDiagnostics, 2022
The COVID-19 pandemic has been a main concern over the last two years and has become one of the most important crises in the history of human health. Today, there is still a need for affordable and reliable diagnostic tests for massive disease monitoring.
Pablo Alberto Franco-Urquijo   +8 more
doaj   +1 more source

Exploring the metabolic and molecular benefits of methyl donor supplementation in a model of metabolic and fatty liver disease

open access: yesAnnals of Hepatology
Introduction and Objectives: Metabolic fatty liver disease (MAFLD) is currently the most common cause of chronic liver damage worldwide. Differential methylation in genes and histones has been correlated with metabolic alterations present in the disease.
Angel Vazquez-Esqueda   +7 more
doaj   +1 more source

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