Results 11 to 20 of about 14,020 (183)

Estrogen-ER-α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 14, Issue 1, January 2024.
Cherubini A, Casirati E, Pelusi S, Valenti L.   +3 more
europepmc   +2 more sources

Novel Para-Phenylenediamine-Based Derivatives as Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization. [PDF]

ChemMedChem
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Smaldone G, Miranda MR, Di Matteo F, Napolitano V, Aliberti M, Musella S, Di Sarno V, Lauro G, Bifulco G, Pepe G, Aquino G, Tecce MF, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Bertamino A, Vestuto V, Ciaglia T.   +17 more
europepmc   +2 more sources

Luspatercept for Transfusion-Dependent Beta-Thalassemia: Real-World Experience in a Large Cohort of Patients From Italy. [PDF]

Am J Hematol
American Journal of Hematology, Volume 100, Issue 9, Page 1651-1655, September 2025.
Origa R, Gianesin B, Zappu A, Denotti AR, Di Giorgio MA, Sciortino R, Motta I, Panzieri DL, Rosso R, Bulla A, Culcasi M, Pasanisi AM, De Franceschi L, Di Maggio R, Pinto VM, Sanna PMG, Ricchi P, Ruffo GB, Schieppati F, Roberti D, Ferrero GB, De Michele E, Arcioni F, Fotzi I, Marktel S, Poloni A, Soverini G, Testa ER, Cabiddu G, Fortugno C, Gigante A, Polese F, Rapezzi D, Sau A, Forni GL, Cappellini MD, Longo F.   +36 more
europepmc   +2 more sources

Traffic light at DSB-transit regulation between gene transcription and DNA repair. [PDF]

FEBS Lett
Upon the generation of a break, DNA damage response activation represses transcription of genes in cis via an ATM‐ and PRC1‐dependent chromatin modification and compaction. Concomitantly, RNAPII accumulates in proximity to DNA ends and locally synthesizes chromatin‐bound ncRNAs.
Modafferi S, Esposito F, Tavella S, Gioia U, Francia S.   +4 more
europepmc   +2 more sources

Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer

Cancer Medicine, Volume 12, Issue 24, Page 22130-22155, December 2023., 2023
Abstract The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present. It is one of the means through which cancer cells actively cope with the potential damaging effects of aneuploidy, a hallmark of most
Diana M. Bravo‐Estupiñan, Karol Aguilar‐Guerrero, Steve Quirós, Man‐Sai Acón, Christian Marín‐Müller, Miguel Ibáñez‐Hernández, Rodrigo A. Mora‐Rodríguez   +6 more
wiley   +1 more source

Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease

Glia, Volume 71, Issue 3, Page 571-587, March 2023., 2023
Main Points Myeloid cells adopt an anti‐inflammatory phenotype in the midbrain and a pro‐inflammatory profile in the striatum of α‐synuclein‐overexpressing mice. Astrocytes in the midbrain of α‐synuclein mice are involved in the pro‐inflammatory reaction.
Leyre Basurco, Miguel Angel Abellanas, Leyre Ayerra, Enrique Conde, Rodrigo Vinueza‐Gavilanes, Esther Luquin, Africa Vales, Amaya Vilas, Patxi San Martin‐Uriz, Ibon Tamayo, Marta M. Alonso, Mikel Hernaez, Gloria Gonzalez‐Aseguinolaza, Pedro Clavero, Elisa Mengual, Montserrat Arrasate, Sandra Hervás‐Stubbs, Maria S. Aymerich   +17 more
wiley   +1 more source

Macrophage migration inhibitory factor gene polymorphisms (SNP ‐173 G>C and STR‐794 CATT5‐8) confer risk of plaque psoriasis: A case–control study

Journal of Clinical Laboratory Analysis, Volume 35, Issue 11, November 2021., 2021
Summary of key results from this study. (1) “Linkage disequilibrium was identified between ‐173 G>C and STR‐794 CATT5‐8 polymorphisms (D′ value = 0.62, r2 = 0.17, p < 0.001, Figure 1). (2) “the ‐173 CC genotype was associated with high MIF serum levels ".
Jorge Hernández‐Bello, Miroslaba Rodríguez‐Puente, Jorge Gutiérrez‐Cuevas, Samuel García‐Arellano, José Francisco Muñoz‐Valle, Mary Fafutis‐Morris, Delfina Guadalupe Villanueva‐Quintero, Anabell Alvarado‐Navarro   +7 more
wiley   +1 more source

Differential Expression and PAH Degradation: What Burkholderia vietnamiensis G4 Can Tell Us?

International Journal of Microbiology, Volume 2020, Issue 1, 2020., 2020
Petroleum is the major energy matrix in the world whose refining generates chemical byproducts that may damage the environment. Among such waste, polycyclic aromatic hydrocarbons (PAH) are considered persistent pollutants. Sixteen of these are considered priority for remediation, and among them is benzo(a)pyrene.
Guilherme Pinto Cauduro, Ana Lusia Leal, Tiago Falcón Lopes, Marcela Marmitt, Victor Hugo Valiati, Todd R. Callaway   +5 more
wiley   +1 more source

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

Frontiers in Cell and Developmental Biology, 2021
We describe, for the first time, a new splice variant of the human TGF-β type II receptor (TβRII). The new transcript lacks 149 nucleotides, resulting in a frameshift and the emergence of an early stop codon, rendering a truncated mature protein of 57 ...
Marcela Soledad Bertolio, Anabela La Colla, Alejandra Carrea, Ana Romo, Gabriela Canziani, Stella Maris Echarte, Sabrina Campisano, German Patricio Barletta, Alexander Miguel Monzon, Tania Melina Rodríguez, Andrea Nancy Chisari, Ricardo Alfredo Dewey   +11 more
doaj   +1 more source

Neuropilin-1: A Conserved Entry Receptor for SARS-CoV-2 and a Potential Therapeutic Target

Biomedicines
Background/Objectives: Neuropilin-1 (NRP1) is a key co-receptor for SARS-CoV-2, complementing the ACE2 receptor. Several investigations have documented highly conserved sequences in this receptor, supporting the implication of NRP1 as a key mediator in ...
Vivany Maydel Sierra-Sánchez, Citlali Margarita Blancas-Napoles, Aina Daniela Sánchez-Maldonado, Indira Medina, Rodrigo Romero-Nava, Fengyang Huang, Enrique Hong, Asdrúbal Aguilera-Méndez, Sergio Adrian Ocampo-Ortega, Santiago Villafaña   +9 more
doaj   +1 more source