Results 21 to 30 of about 14,058 (179)

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

open access: yesFrontiers in Cell and Developmental Biology, 2021
We describe, for the first time, a new splice variant of the human TGF-β type II receptor (TβRII). The new transcript lacks 149 nucleotides, resulting in a frameshift and the emergence of an early stop codon, rendering a truncated mature protein of 57 ...
Marcela Soledad Bertolio   +11 more
doaj   +1 more source

Neuropilin-1: A Conserved Entry Receptor for SARS-CoV-2 and a Potential Therapeutic Target

open access: yesBiomedicines
Background/Objectives: Neuropilin-1 (NRP1) is a key co-receptor for SARS-CoV-2, complementing the ACE2 receptor. Several investigations have documented highly conserved sequences in this receptor, supporting the implication of NRP1 as a key mediator in ...
Vivany Maydel Sierra-Sánchez   +9 more
doaj   +1 more source

Princípios de terapia génica [PDF]

open access: yes, 2016
Podríamos definir la terapia génica como la introducción de un gen foráneo en el ser humano con fines terapéuticos. La terapia génica comenzó a ser utilizada en el ser humano a principios de los años 90 y en los últimos años ha empezado a dar sus frutos.
Reverter Velasco, Naiara
core  

A Photonastic Prototissue Capable of Photo‐Mechano‐Chemical Transduction

open access: yesAdvanced Materials, Volume 37, Issue 40, October 9, 2025.
Mimicking energy transduction in prototissue assemblies remains a challenge of bottom‐up synthetic biology. In this work, prototissues integrating protocells with photothermal gold nanoparticle proto‐organelles and a thermoresponsive polymeric proto‐cortex are developed.
Agostino Galanti   +7 more
wiley   +1 more source

PF435 A FLEXIBLE THERAPEUTIC STRATEGY FOR LEUKEMIA USING EX‐VIVO EXPANDED T CELLS COMBINED WITH BISPECIFIC ANTIBODIES

open access: yesHemaSphere, Volume 3, Issue S1, Page 170-171, June 2019., 2019
Background: Cytokine induced killer cells (CIK) are an advanced therapeutic medicinal product (ATMP) composed of activated, mostly CD8+, T cells with anti‐tumor but little graft versus host disease (GvHD) activity, even in an allogeneic setting.
J. Golay   +5 more
wiley   +1 more source

Protective Effects of Moringa oleifera on HBV Genotypes C and H Transiently Transfected Huh7 Cells

open access: yesJournal of Immunology Research, 2017
Chronic hepatitis B infection treatment implicates a long-lasting treatment. M. oleifera extracts contain compounds with antiviral, antioxidant, and antifibrotic properties. In this study, the effect of M.
Sina Feustel   +6 more
doaj   +1 more source

Coacervate Vesicles as Adaptive Platforms for Synthetic Biology and Smart Materials

open access: yesChemistry – A European Journal, Volume 31, Issue 54, September 24, 2025.
Coacervate vesicles are emerging protocells that merge coacervates’ functionality within membranised architectures. Their diverse formation mechanisms from coacervate droplets yield tunable, responsive systems with broad potential, from synthetic biology to smart materials, offering a powerful, programmable platform for next‐generation bioinspired ...
Francesco Vicentini   +2 more
wiley   +1 more source

PF436 GMP MANUFACTURING OF ALLOGENEIC CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) CYTOKINE INDUCED KILLER (CIK) CELLS WITH SLEEPING BEAUTY (SB) TRANSPOSON FOR ADOPTIVE IMMUNOTHERAPY

open access: yesHemaSphere, Volume 3, Issue S1, Page 171, June 2019., 2019
Background: Immunotherapy using patient‐derived T cells engineered to express a chimeric antigen receptor (CAR) by viral vectors has achieved complete remission and durable response in highly refractory populations. Unmodified allogeneic Cytokine Induced Killer (CIK) cells (CD3+CD56+ T cells) have clearly demonstrated a high profile of safety in ALL ...
C.F. Magnani   +22 more
wiley   +1 more source

Nuevos politriazoles protonables para terapia génica [PDF]

open access: yes, 2018
La terapia génica consiste en utilizar genes para tratar o prevenir enfermedades. En la actualidad es quizás junto a la inmunonoterapia una de las estrategias más prometedoras en lo que se refiere al tratamiento del cáncer.
Ramírez Espinosa, María
core  

Cerium oxide nanoparticles: a promising nanotherapy approach for chronic degenerative diseases

open access: yesJournal of Materials Science: Materials in Engineering
Oxidative stress is a process caused by excess-free radicals and reactive oxygen species (ROS), which contribute to the onset and progression of various chronic degenerative diseases.
Hugo Christian Monroy-Ramirez   +7 more
doaj   +1 more source

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