Results 31 to 40 of about 14,058 (179)

Attenuation of Pulmonary Damage Associated with COPD in a Cadmium-Exposed Model Due to the Administration of a siRNA Targeting PAD4

Scientia Pharmaceutica
Chronic obstructive pulmonary disease (COPD), characterised by persistent airflow limitation during breathing, is considered to be the third leading cause of death worldwide.
Sergio Adrian Ocampo-Ortega, Sandra Edith Cabrera-Becerra, Vivany Maydel Sierra-Sanchez, Vanessa Giselle García-Rubio, Citlali Margarita Blancas-Napoles, Rodrigo Romero-Nava, Fengyang Huang, Enrique Hong, Asdrúbal Aguilera-Méndez, Santiago Villafaña   +9 more
doaj   +1 more source

PF437 PLATINUM TALEN‐MEDIATED NON‐VIRAL T CELL RECEPTOR GENE KNOCK‐IN FACILITATES UNIVERSAL T CELL GENOME EDITING FOR MANUFACTURING OF THERAPEUTIC IMMUNE CELLS

HemaSphere, Volume 3, Issue S1, Page 171-172, June 2019., 2019
Background: Adoptive transfer of T cells genetically modified to express T‐cell receptors (TCRs) directed against tumor‐specific antigens is an emerging therapeutic tool for refractory hematologic and non‐hematologic neoplasms. Although accumulating experiences in their clinical use have shown great promise, challenges still remain because mispairing ...
Y. Honjo, T. Kawase, T. Miyama, H. Sato, R. Suzuki, T. Sakuma, T. Yamamoto, T. Ichinohe   +7 more
wiley   +1 more source

Optogenética y posibles terapias para la retinosis pigmentaria [PDF]

, 2019
La retinosis pigmentaria (RP) es un grupo clínico y genéticamente heterogéneo de trastornos de la retina hereditarios caracterizados por una disfunción progresiva difusa de fotorreceptores predominantemente bastón, con la posterior degeneración de ...
Sansa Fayos, Marc
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Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

A terapia gênica e os princípios éticos [PDF]

, 2003
Gene therapy is a form of genetic manipulation which tries to correct or to diminish the effects caused by genetic diseases. There are great hopes for the development of this type of therapy, specially for somatic genetic diseases that has no cure, but ...
Rodríguez Yunta, Eduardo
core   +1 more source

Los genes: del laboratorio a la prensa [PDF]

, 2001
La información sobre temas relacionados con genética comienza su auge en los medios de comunicación en 1999. En el informe Quiral del citado año reflejaba cómo los artículos periodísticos relacionados con la genética iniciaban un importante incremento ...
López Jornet, Gemma, Semir Frappart, David de   +1 more
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Pirfenidone slows the development of fibrosis and malignant neoplasms by modulating inflammation in an experimental model of hepatocarcinoma.

Annals of Hepatology
Introduction and objectives: Hepatocellular carcinoma (HCC) is the most common liver neoplasm in the world. Inflammatory, oxidative and fibrogenic processes are key in tumor development and propagation.
Scarlet Arceo-Orozco, Fernado Caloca-Camarena, Marina Galicia-Moreno, Hugo C. Monroy-Ramírez, Juan Armendáriz-Borunda   +4 more
doaj   +1 more source

Terapia gênica

Clinical and Biomedical Research, 2022
A terapia gênica está baseada no conceito de que uma doença genética pode ser corrigida pela substituição ou adição do gene defeituoso. Muita expectativa foi gerada pelos primeiros protocolos, mas o surgimento de complicações inesperadas levou a uma ...
Cláudia D. da Silva, Úrsula Silveira Matte, Roberto Giugliani   +2 more
doaj  

Traffic light at DSB–transit regulation between gene transcription and DNA repair

FEBS Letters, Volume 599, Issue 2, Page 177-189, January 2025.
Upon the generation of a break, DNA damage response activation represses transcription of genes in cis via an ATM‐ and PRC1‐dependent chromatin modification and compaction. Concomitantly, RNAPII accumulates in proximity to DNA ends and locally synthesizes chromatin‐bound ncRNAs.
Stefania Modafferi, Francesca Esposito, Sara Tavella, Ubaldo Gioia, Sofia Francia   +4 more
wiley   +1 more source

Edición de genes mediante crispr-cas9: más que Cortar y pegar [PDF]

, 2019
En esta revisión se exponen las características y aplicaciones de CRISPR-Cas9, un sistema inmune adaptativo propio de algunas especies de bacterias y arqueas que lo utilizan para defenderse de bacteriófagos.
Fernández Palacios, Pablo
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