Results 151 to 160 of about 13,919 (330)

Gene and Teratogen Induced Defects of Early Central Nervous System Development [PDF]

open access: yes, 1986
The events involved in the histogenesis of the primitive nervous system involve precise control over cell shape changes, cellular migrations, cell-cell and cell-extracellular matrix interactions.
O\u27Shea, K. S.
core  

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

open access: yesExperimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores   +4 more
wiley   +1 more source

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley   +1 more source

Psychotropic medication and the fetal brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Brain region changes linked to in‐utero psychotropic exposure. Abstract Medications known to cross the blood–brain barrier (psychotropic medications) are commonly prescribed to women during pregnancy, often for the management of mental illness.
Oliver Gale‐Grant, Tomoki Arichi
wiley   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida   +7 more
wiley   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

MONDE·T: A database and interactive webserver for non‐standard amino acids and peptide components in the PDB

open access: yesProtein Science, Volume 35, Issue 11, November 2026.
Abstract Non‐standard amino acids (ncAAs) together with synthetic additions (like caps and linkers) are of wide interest for protein design and pharmaceutical optimization, as they can improve physicochemical properties and possibly reshape protein structure. Their inclusion in experimental structures has not been explored systematically.
Alex Waldherr   +2 more
wiley   +1 more source

Total duplication of the femur and polydactyly in the same limb of a Korean native calf

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract This case report describes a neonatal Korean native calf presenting with total duplication of the femur and polydactyly within the same hindlimb—an extremely rare congenital anomaly not previously reported in cattle. The calf exhibited marked structural deformities and inability to stand independently.
Geonil Moon, Suyoung Heo, Namsoo Kim
wiley   +1 more source

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