Results 251 to 260 of about 48,551 (323)
Some of the next articles are maybe not open access.
Journal of Psychopharmacology, 1992
Animal tests for teratogenicity of drugs have more medicolegal and political significance than relevance to human therapeutics. Test conditions differ widely from human therapeutic regimens and major species differences are common. Occasionally the tests will define a drug or group of drugs with an unpleasant potential, and sometimes a mode of action ...
D F Hawkins
exaly +3 more sources
Animal tests for teratogenicity of drugs have more medicolegal and political significance than relevance to human therapeutics. Test conditions differ widely from human therapeutic regimens and major species differences are common. Occasionally the tests will define a drug or group of drugs with an unpleasant potential, and sometimes a mode of action ...
D F Hawkins
exaly +3 more sources
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment [PDF]
Toxicological Sciences, 2022 Current animal-free methods to assess teratogenicity of drugs under development still deliver high numbers of false negatives. To improve the sensitivity of human teratogenicity prediction, we characterized the TeraTox test, a newly developed ...
Stefan Kustermann +2 more
exaly +3 more sources
Development of a zebrafish embryo teratogenicity assay and quantitative prediction model
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2010K. Brannen +3 more
exaly +2 more sources
Field cyanobacterial blooms producing retinoid compounds cause teratogenicity in zebrafish embryos.
Chemosphere, 2020Cyanobacteria routinely release potentially harmful bioactive compounds into the aquatic environment. Several recent studies suggested a potential link between the teratogenicity of effects caused by cyanobacteria and production of retinoids.
M. Pípal +5 more
semanticscholar +1 more source
Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing [PDF]
Reproductive Toxicology, 2020 Human induced pluripotent stem cells (hiPSC) were used to develop an assay format that may deliver information on teratogenicity of drugs. A human pluripotent stem cell scorecard panel was used to monitor the expression of 96 marker genes that are ...
Stefan Kustermann +2 more
exaly +2 more sources
Journal of American Academy of Dermatology, 2019
Background: This systematic review assesses effects of paternal exposure to dermatologic medications by using the former US Food and Drug Administration (FDA) pregnancy categories as a benchmark.
G. Zakhem, C. Motosko, E. Mu, R. Ho
semanticscholar +1 more source
Background: This systematic review assesses effects of paternal exposure to dermatologic medications by using the former US Food and Drug Administration (FDA) pregnancy categories as a benchmark.
G. Zakhem, C. Motosko, E. Mu, R. Ho
semanticscholar +1 more source
American Journal of Industrial Medicine, 1983
Reproduction can be impaired in animals and man by drugs and various environmental agents. Depending on the time of exposure—from fertilization through the fetal period and eventually during lactation—the consequences can range from embryotoxicity, gross malformations and a large variety of more subtle morphological, biochemical, and functional ...
openaire +4 more sources
Reproduction can be impaired in animals and man by drugs and various environmental agents. Depending on the time of exposure—from fertilization through the fetal period and eventually during lactation—the consequences can range from embryotoxicity, gross malformations and a large variety of more subtle morphological, biochemical, and functional ...
openaire +4 more sources
Genotoxicity and teratogenicity of seabuckthorn (Hippophae rhamnoides L.) berry oil
Drug and chemical toxicology (New York, N.Y. 1978), 2018As botanicals and dietary supplements are used increasingly in many countries, the issue of safety is particularly critical for regulation of food products containing these substances. Seabuckthorn (Hippophae rhamnoides L.) has been used for centuries as
Pingjing Wen +6 more
semanticscholar +1 more source