Results 1 to 10 of about 4,182 (225)

Detection of Thalidomide Embryotoxicity by In Vitro Embryotoxicity Testing Based on Human iPS Cells

open access: yesJournal of Pharmacological Sciences, 2014
The mouse embryonic stem cell test (mEST) is used to assess the embryotoxicity of drug candidates by evaluating the effects on the cardiac differentiation of stem cells. However, thalidomide embryotoxicity has not yet been reported using the mEST.
Nobuo Aikawa   +5 more
exaly   +6 more sources

Rearing Sea Urchins to Promote ‘Ready-to-Spawn’ Conditions for Ecotoxicological Surveys [PDF]

open access: yesToxics
The sea urchin Paracentrotus lividus is a good model in ecotoxicology, but adults living along the Italian coasts have a limited reproductive period.
Roberta Miroglio   +7 more
doaj   +2 more sources

Toxicological Effects of Glufosinate-Ammonium-Containing Commercial Formulations on Biomphalaria glabrata in Aquatic Environments: A Multidimensional Study from Embryotoxicity to Histopathology [PDF]

open access: yesToxics
Glufosinate-ammonium (GLA) is a broad-spectrum herbicide widely used for weed control. However, its potential toxic effects on non-target aquatic organisms, especially in freshwater ecosystems, are of growing concern.
Yuncheng Qian   +9 more
doaj   +2 more sources

Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117

open access: yesMolecules, 2022
Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessible Serratia ...
Jelena Lazic   +8 more
doaj   +1 more source

Study of the specific toxic effects of the substance 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil, the original non-nucleoside inhibitor of human immunodeficiency virus type 1 (Retroviridae; Orthoretrovirinae; Lentivirus: Human immunodeficiency virus 1) reverse transcriptase

open access: yesВопросы вирусологии, 2021
Introduction. Combination antiretroviral therapy is currently the main component of treatment for human immunodeficiency virus (HIV) infected patients.
E. A. Gaidai   +7 more
doaj   +1 more source

The overview of current evidence on the reproductive toxicity of dibutyl phthalate

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2021
Over the past years, many legitimate concerns have been raised about the effects of dibutyl phthalate (DBP) as an endocrine disruptor, especially on reproduction.
Ewelina Czubacka   +2 more
doaj   +1 more source

The Embryotoxicity of Some Phenol Derivatives on Zebrafish, Danio rerio [PDF]

open access: yesCaspian Journal of Environmental Sciences, 2019
The existence of toxicants in ecosystems has been increased dramatically in recent years, especially in aquatic environments. Phenols and chlorinated phenol derivatives are toxic industrial compounds. Phenols and derivatives are known to be environmental
Z Ceylan, T Sisman, H Dane, Ş Adil
doaj   +1 more source

Iphiona mucronata (Forssk.) Asch. & Schweinf. A Comprehensive Phytochemical Study via UPLC-Q-TOF-MS in the Context of the Embryo- and Cytotoxicity Profiles

open access: yesMolecules, 2022
Iphiona mucronata (Family Asteraceae) is widely distributed in the Eastern desert of Egypt. It is a promising plant material for phytochemical analysis and pharmacologic studies, and so far, its specific metabolites and biological activity have not yet ...
Łukasz Pecio   +9 more
doaj   +1 more source

Determination of embryotoxic dose limit of detomidine with in-ovo model [PDF]

open access: yesEurasian Journal of Veterinary Sciences, 2021
Aim: The aim of this study is to determine the embryotoxic dose limit of detomidine with an in-ovo model using fertile hen?s eggs. Materials and Methods: 210 fertile eggs were divided into 7 equal (n: 30) groups and placed in the incubator under optimum ...
Rahmi Canbar   +3 more
doaj  

The embryotoxicity of gossypol [PDF]

open access: yesTeratology, 1985
AbstractIn utero development was analyzed in pregnancies that resulted from matings between gossypol‐treated male rats and untreated female rats and in pregnancies in which gossypol was administered to the pregnant rat only. Gossypol treatment of males had no effect on the outcome of pregnancy.
openaire   +3 more sources

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