Results 1 to 10 of about 375 (116)

Detection of Thalidomide Embryotoxicity by in Vitro Embryotoxicity Testing Based on Human iPS Cells

Journal of Pharmacological Sciences, 2014
The mouse embryonic stem cell test (mEST) is used to assess the embryotoxicity of drug candidates by evaluating the effects on the cardiac differentiation of stem cells. However, thalidomide embryotoxicity has not yet been reported using the mEST.
Nobuo Aikawa, Atsushi Kunisato, Kenji Nagao, Hideaki Kusaka, Katsumi Takaba, Kinya Ohgami   +5 more
exaly   +6 more sources

Sublethal Effects of Polystyrene Nanoplastics on the Embryonic Development of Artemia salina (Linnaeus, 1758)

Animals, 2023
Currents, wave motion, solar radiation, and abrasion are mechanisms responsible for the degradation of large plastic artifacts and contribute to the dispersion of micro and nanoplastics into aquatic ecosystems, which are, currently, the most dangerous ...
Martina Contino, Greta Ferruggia, Stefania Indelicato, Roberta Pecoraro, Elena Maria Scalisi, Antonio Salvaggio, Maria Violetta Brundo   +6 more
doaj   +1 more source

Modulatory Effects of Arctostaphylos uva-urs Extract In Ovo Injected into Broiler Embryos Contaminated by Aflatoxin B1

Animals, 2022
In ovo injection of nutrients can modulate the embryo’s physiological responses against aflatoxin B1 (AFB1) embryotoxicity. This hypothesis was tested using in ovo injection of Arctostaphylos uva-ursi (Ar. uu.) methanolic extract.
Hamada Elwan, Abdelhameed S. A. Mohamed, Dawood Hosni Dawood, Shaaban S. Elnesr   +3 more
doaj   +1 more source

Comparative Toxicity Assessment of Kratom Decoction, Mitragynine and Speciociliatine Versus Morphine on Zebrafish (Danio rerio) Embryos

Frontiers in Pharmacology, 2021
Background: Kratom (Mitragyna speciosa Korth), a popular opioid-like plant holds its therapeutic potential in pain management and opioid dependence. However, there are growing concerns about the safety or potential toxicity risk of kratom after prolonged
Thenmoly Damodaran, Nelson Jeng-Yeou Chear, Vikneswaran Murugaiyah, Mohd Nizam Mordi, Surash Ramanathan   +4 more
doaj   +1 more source

Bioprospecting of Less-Polar Constituents from Endemic Brown Macroalga Fucus virsoides J. Agardh from the Adriatic Sea and Targeted Antioxidant Effects In Vitro and In Vivo (Zebrafish Model)

Marine Drugs, 2021
The endemic brown macroalga Fucus virsoides J. Agardh from the Adriatic Sea was in the focus of the present research. The volatiles of fresh (FrFv) and air-dried (DrFv) samples of F.
Igor Jerković, Ana-Marija Cikoš, Sanja Babić, Lara Čižmek, Krunoslav Bojanić, Krunoslav Aladić, Nikolay V. Ul’yanovskii, Dmitry S. Kosyakov, Albert T. Lebedev, Rozelindra Čož-Rakovac, Polonca Trebše, Stela Jokić   +11 more
doaj   +1 more source

Phytochemical and Safety Evaluations of Zingiber ottensii Valeton Essential Oil in Zebrafish Embryos and Rats

Toxics, 2021
Zingiber ottensii Valeton (ZO) exhibits pharmacological activity and has long been used in traditional medicine. However, reports about its safety profiles are limited.
Wisit Thitinarongwate, Raktham Mektrirat, Wutigri Nimlamool, Parirat Khonsung, Surachai Pikulkaew, Siriporn Okonogi, Puongtip Kunanusorn   +6 more
doaj   +1 more source

The embryotoxicity of gossypol [PDF]

Teratology, 1985
AbstractIn utero development was analyzed in pregnancies that resulted from matings between gossypol‐treated male rats and untreated female rats and in pregnancies in which gossypol was administered to the pregnant rat only. Gossypol treatment of males had no effect on the outcome of pregnancy.
openaire   +3 more sources

Development of technique for in vitro embryotoxicity of dental biomaterials

Japanese Dental Science Review, 2016
The Embryonic Stem Cell Test (EST) developed in Germany in 1997 is known as a screening test method capable of predicting the presence of unknown chemicals influencing normal human development.
Koichi Imai, D.D.S., Ph.D.
doaj   +1 more source

Embryotoxicity assays for leached components from dental restorative materials

Reproductive Biology and Endocrinology, 2011
Background Currently, there are no suitable assays available to evaluate the embryotoxicity of leached components from restorative dental materials. Methods The effect of the medium conditioned by composites and amalgam on mouse blastocysts in vitro was ...
Mummolo Stefano, Tecco Simona, Gallusi Gianni, Farini Donatella, Klinger Francesca G, Marzo Giuseppe, Libonati Antonio, De Felici Massimo, Campanella Vincenzo   +8 more
doaj   +1 more source

Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117

Molecules, 2022
Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessible Serratia ...
Jelena Lazic, Sanja Skaro Bogojevic, Sandra Vojnovic, Ivana Aleksic, Dusan Milivojevic, Martin Kretzschmar, Tanja Gulder, Milos Petkovic, Jasmina Nikodinovic-Runic   +8 more
doaj   +1 more source