Results 11 to 20 of about 2,310 (177)

Severe Embryotoxicity of Artemisinin Derivatives in Experimental Animals, but Possibly Safe in Pregnant Women

open access: yesMolecules, 2009
Preclinical studies in rodents have demonstrated that artemisinins, especially injectable artesunate, can induce fetal death and congenital malformations at a low dose range.
Qigui Li, Peter J. Weina
doaj   +2 more sources

In vitro embryotoxicity and mode of antibacterial mechanistic study of gold and copper nanoparticles synthesized from Angelica keiskei (Miq.) Koidz. leaves extract [PDF]

open access: yes, 2021
The present study demonstrated the in vitro embryotoxicity assessment of gold nanoparticles (AuNPs) and copper nanoparticles (CuNPs) prepared from the leaves extract of Angelica keiskei (Miq.) Koidz.
Krishnaraj, Chandran   +5 more
core   +1 more source

Evaluation of Embryotoxicity of Radix scutellariae Based on Embryonic Stem Test [PDF]

open access: yes, 2015
Purpose: To determine the potential embryotoxicity of Radix scutellariae (RS) extract using an embryonic stem cell test (EST) and to evaluate its effect on the differentiation of mouse embryonic stem (ES) cells.Methods: All the test samples were obtained
Huang, A   +5 more
core   +1 more source

Phytochemical and Safety Evaluations of Volatile Terpenoids from Zingiber cassumunar Roxb. on Mature Carp Peripheral Blood Mononuclear Cells and Embryonic Zebrafish

open access: yesMolecules, 2020
Pharmaceutical products of essential oil from Zingiber cassumunar Roxb. are extensively being developed, while the research on their safety is seldom documented.
Raktham Mektrirat   +4 more
doaj   +1 more source

Study of the specific toxic effects of the substance 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil, the original non-nucleoside inhibitor of human immunodeficiency virus type 1 (Retroviridae; Orthoretrovirinae; Lentivirus: Human immunodeficiency virus 1) reverse transcriptase

open access: yesВопросы вирусологии, 2021
Introduction. Combination antiretroviral therapy is currently the main component of treatment for human immunodeficiency virus (HIV) infected patients.
E. A. Gaidai   +7 more
doaj   +1 more source

Barbatic Acid Offers a New Possibility for Control of Biomphalaria Glabrata and Schistosomiasis

open access: yesMolecules, 2017
This study evaluated the biological activity of an ether extract and barbatic acid (BAR) from Cladia aggregata on embryos and adult mollusks of Biomphalaria glabrata, cercariae of Schistosoma mansoni and the microcrustacean Artemia salina.
Mônica Cristina Barroso Martins   +9 more
doaj   +1 more source

Chloroquine embryotoxicity in the postimplantation rat conceptus in vitro [PDF]

open access: yes, 1993
The embryotoxicity of the antimalarial drug chloroquine (CQ) was evaluated in vitro using the rat whole embryo culture system. CQ was found to be embryotoxic and dysmorphogenic when added directly to the culture media containing gestational day (GD) 10 ...
Ambroso, Jeffrey L.   +3 more
core   +1 more source

Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants

open access: yesPlants, 2020
The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput ...
Amir Modarresi Chahardehi   +2 more
doaj   +1 more source

The overview of current evidence on the reproductive toxicity of dibutyl phthalate

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2021
Over the past years, many legitimate concerns have been raised about the effects of dibutyl phthalate (DBP) as an endocrine disruptor, especially on reproduction.
Ewelina Czubacka   +2 more
doaj   +1 more source

EMBRYOTOXIC AND TERATOGENIC EFFECT OF DISODIUM GLYCYRRHETINIC ACID HEMIPHTHALATE IN MICE [PDF]

open access: yesActa Medica Iranica, 1998
Disodium glycyrrhetinic acid hemiphthalaic (GAP) was evaluated for developmental toxicity in pregnant NMRI mice. GAP was administered intrapcritoneally on days S, 9, 10, of gestation at doses of 0, 25, 50 and 75 mg/kg/dav.
H. Marzbnn
doaj   +1 more source

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