Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells [PDF]
Cell Death Discovery, 2023 Summary Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, and time-consuming. Often, studies are not of human relevance because of species differences.
Anna Cherianidou +11 more
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Exposure to potentially teratogenic medications before and during the first trimester of pregnancy compared to women of childbearing age: A retrospective analysis of Swiss claims data (2015–2021) [PDF]
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Exposure to potentially teratogenic medications during pregnancy is underinvestigated in Switzerland. We aimed to assess exposure to potential teratogens preconceptionally, during the first trimester, and in women of childbearing age, and ...
Carole A. Marxer +5 more
doaj +2 more sources
Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment [PDF]
Frontiers in ToxicologyIntroductionExposure to teratogenic compounds during pregnancy can lead to significant birth defects. Given the considerable variation in drug responses across species, along with the financial and ethical challenges associated with animal testing, the ...
José M. Horcas-Nieto +11 more
doaj +2 more sources
Comparative analysis of teratogen-induced malformations and gene expression across zebrafish strains in early development [PDF]
Toxicology ReportsZebrafish embryos are widely used in developmental toxicity testing. However, the extent to which genetic background influences susceptibility to teratogenic compounds remains incompletely understood.
Chitose Taya +6 more
doaj +2 more sources
Experiences of sexual and reproductive health screening and counseling in the clinical setting among adolescents and young adults with rheumatic disease [PDF]
Pediatric Rheumatology Online JournalBackground Our objective was to describe differences among adolescents and young adults (AYAs) with rheumatic disease using teratogens compared to non-users in receipt of sexual and reproductive health (SRH) counseling, teratogenicity knowledge ...
Brittany Huynh +2 more
doaj +2 more sources
Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. [PDF]
, 2015 Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence.
Bouvet, Michael +8 more
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Viruses, 2021 Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in
Julia A. Gomes +11 more
doaj +1 more source
A standardized human embryoid body platform for the detection and analysis of teratogens. [PDF]
PLoS ONE, 2017 Teratogens are compounds that can induce birth defects upon exposure of the developing fetus. To date, most teratogen studies utilize pregnant rodents to determine compound teratogenicity in vivo.
Anthony Flamier +2 more
doaj +1 more source
Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review
Frontiers in Genetics, 2021 Since the 1960s, drugs have been known to cause teratogenic effects in humans. Such teratogenicity has been postulated to be influenced by genetics. The aim of this review was to provide an overview of the current knowledge on genetic susceptibility to ...
Julia do Amaral Gomes +22 more
doaj +1 more source
From the Farm to the Lab: How Chicken Embryos Contribute to the Field of Teratology
Frontiers in Genetics, 2021 Congenital anomalies and its causes, particularly, by external factors are the aim of the field called teratology. The external factors studied by teratology are known as teratogens and can be biological or environmental factors for example, chemicals ...
Gabriela Elis Wachholz +10 more
doaj +1 more source