Results 1 to 10 of about 6,483 (296)
A standardized human embryoid body platform for the detection and analysis of teratogens. [PDF]
PLoS ONE, 2017 Teratogens are compounds that can induce birth defects upon exposure of the developing fetus. To date, most teratogen studies utilize pregnant rodents to determine compound teratogenicity in vivo.
Anthony Flamier +2 more
doaj +2 more sources
Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells [PDF]
Cell Death Discovery, 2023 Summary Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, and time-consuming. Often, studies are not of human relevance because of species differences.
Anna Cherianidou +11 more
doaj +2 more sources
F1000Research, 2016 Background: Acute high dose exposure to teratogenic chemicals alters the proper development of an embryo leading to infertility, impaired fecundity, and few viable offspring.
Alexis Killeen +1 more
doaj +2 more sources
Pregnancy and neonatal outcomes after periconceptional exposure to isotretinoin in Koreans [PDF]
Obstetrics & Gynecology Science, 2022 Objective Isotretinoin should not be used during pregnancy because of the risk of birth defects. Most pregnant women exposed to isotretinoin choose voluntary pregnancy termination due to concerns about birth defects.
Eun-Hwan Cha +9 more
doaj +1 more source
Viruses, 2021 Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in
Julia A. Gomes +11 more
doaj +1 more source
Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review
Frontiers in Genetics, 2021 Since the 1960s, drugs have been known to cause teratogenic effects in humans. Such teratogenicity has been postulated to be influenced by genetics. The aim of this review was to provide an overview of the current knowledge on genetic susceptibility to ...
Julia do Amaral Gomes +22 more
doaj +1 more source
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Frontiers in Pharmacology, 2023 Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain development, leading to a continuum of neurodevelopmental difficulties.
R. L. Bromley +31 more
doaj +1 more source
Frontiers in Genetics, 2021 The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still remain.
Thayne Woycinck Kowalski +29 more
doaj +1 more source
A Religious Approach to the Role of Mothers in the function of Teratogens [PDF]
زن در فرهنگ و هنر, 2013 The role of the motherhood is the most important factor in individual and social life of the human beings. Mother willingly and /or, unwillingly, plays her role in the destination of child via various factors.
Fahimeh Farahmandpour, Reza Firouzi
doaj +1 more source
Teratogenicity with Olanzapine
Indian Journal of Psychological Medicine, 2014 Olanzapine, a 2(nd) generation antipsychotic, is in use in the clinical practice for nearly a decade and a half now. It is classified as a category C drug with very few reports of its toxic effects on the fetus. In general, the risk benefit analysis warrants its use in pregnancy.
Sathya Prakash, Rakesh Kumar Chadda
openaire +4 more sources