Exposure to potentially teratogenic medications before and during the first trimester of pregnancy compared to women of childbearing age: A retrospective analysis of Swiss claims data (2015–2021) [PDF]
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Exposure to potentially teratogenic medications during pregnancy is underinvestigated in Switzerland. We aimed to assess exposure to potential teratogens preconceptionally, during the first trimester, and in women of childbearing age, and ...
Carole A. Marxer +5 more
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Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment [PDF]
Frontiers in ToxicologyIntroductionExposure to teratogenic compounds during pregnancy can lead to significant birth defects. Given the considerable variation in drug responses across species, along with the financial and ethical challenges associated with animal testing, the ...
José M. Horcas-Nieto +11 more
doaj +2 more sources
Comparative analysis of teratogen-induced malformations and gene expression across zebrafish strains in early development [PDF]
Toxicology ReportsZebrafish embryos are widely used in developmental toxicity testing. However, the extent to which genetic background influences susceptibility to teratogenic compounds remains incompletely understood.
Chitose Taya +6 more
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Cell Death Discovery, 2023 Summary Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, and time-consuming. Often, studies are not of human relevance because of species differences.
Anna Cherianidou +11 more
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Viruses, 2021 Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in
Julia A. Gomes +11 more
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Pregnancy and neonatal outcomes after periconceptional exposure to isotretinoin in Koreans [PDF]
Obstetrics & Gynecology Science, 2022 Objective Isotretinoin should not be used during pregnancy because of the risk of birth defects. Most pregnant women exposed to isotretinoin choose voluntary pregnancy termination due to concerns about birth defects.
Eun-Hwan Cha +9 more
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A standardized human embryoid body platform for the detection and analysis of teratogens. [PDF]
PLoS ONE, 2017 Teratogens are compounds that can induce birth defects upon exposure of the developing fetus. To date, most teratogen studies utilize pregnant rodents to determine compound teratogenicity in vivo.
Anthony Flamier +2 more
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Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review
Frontiers in Genetics, 2021 Since the 1960s, drugs have been known to cause teratogenic effects in humans. Such teratogenicity has been postulated to be influenced by genetics. The aim of this review was to provide an overview of the current knowledge on genetic susceptibility to ...
Julia do Amaral Gomes +22 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Congenital Zika Syndrome (CZS) occurs in up to 42% of individuals exposed to ZIKV prenatally. Deregulation in gene expression and protein levels of components of the p53 signaling pathway, such as p53 and MDM2, due to ZIKV infection has been reported ...
Julia A. Gomes +26 more
doaj +1 more source
Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies
Frontiers in Pharmacology, 2023 Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain development, leading to a continuum of neurodevelopmental difficulties.
R. L. Bromley +31 more
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